toe-2 Target of ERK kinase mpk-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: toe-2
Official Full Name: Target of ERK kinase mpk-1
Primary source: WormBase:WBGene00016971
Locus tag: CELE_C56E6.3
See related: AllianceGenome:WB:WBGene00016971
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinase activity. Involved in positive regulation of apoptotic process and regulation of asymmetric cell division. Predicted to be located in several cellular components, including centrosome; chromosome; and midbody. Is expressed in several structures, including QL; QL.aa; QL.pp; QR; and oxygen sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See toe-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (6517188..6521385, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
Title: NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms.
Title: The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C56E6.3 (e-PCR)
- UniSTS:309444

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Target of ERK kinase mpk-1

NP_001022043.1

Confirmed by transcript evidence

NP_001370609.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6517188..6521385 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026872.4 → NP_001022043.1 Target of ERK kinase mpk-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022043.1

Status: REVIEWED

UniProtKB/TrEMBL

Q65ZJ1

Conserved Domains (1) summary

cl02442
Location:98 → 161

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
NM_001383867.2 → NP_001370609.1 Target of ERK kinase mpk-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZH5, Q65ZJ1

Conserved Domains (1) summary

cl02442
Location:91 → 160

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...