Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka5provided by MGI
Official Full Name: ribosomal protein S6 kinase, polypeptide 5provided by MGI
Primary source: MGI:MGI:1920336
See related: Ensembl:ENSMUSG00000021180 AllianceGenome:MGI:1920336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSK1; RLPK; RLSK; MSPK1; S6K-alpha-5; 3110005L17Rik; 6330404E13Rik
Summary: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of DNA-templated transcription; and regulation of postsynapse organization. Located in nucleus. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 5.5), CNS E18 (RPKM 4.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 50.81 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (100514692..100691693, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (100548439..100725328, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.
Title: MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.
Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis.
Title: Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis.
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Title: Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells.
Title: Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells.
Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis.
Title: Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis.
Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
Title: Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.
Title: Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.
These results indicate the relevance of CX3CL1 in the activation of the pro-inflammatory NF-kappaB signalling pathway through MSK1 in microglial cells.
Title: Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells.
These data suggest that the kinase activity of MSK1 is not directly required for several forms of synaptic plasticity or spatial learning and memory.
Title: The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.
These data of this study provided important new insights into the mechanism by which the MAPK/MSK1 signaling cassette confers neuroprotection against excitotoxic insults.
Title: Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Mit231 (e-PCR), detects polymorphism
- UniSTS:126786

RH138282 (e-PCR)
- UniSTS:220369

AI854034 (e-PCR)
- UniSTS:180451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S10 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3S28 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-5

Names: 90 kDa ribosomal protein S6 kinase 5; RSK-like protein kinase; nuclear mitogen- and stress-activated protein kinase 1

NP_001317631.1

EC 2.7.11.1

NP_705815.1

EC 2.7.11.1

XP_006516338.1

EC 2.7.11.1

XP_030102809.1

EC 2.7.11.1

XP_030102810.1

EC 2.7.11.1

XP_036013517.1

EC 2.7.11.1

XP_036013518.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330702.1 → NP_001317631.1 ribosomal protein S6 kinase alpha-5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC123705, AC159818, AK032316, AK160758, BQ174267, CX207283

Consensus CDS

CCDS88388.1

UniProtKB/Swiss-Prot

Q8C050

UniProtKB/TrEMBL

Q3TUH8

Related

ENSMUSP00000152481.2, ENSMUST00000222731.2
NM_153587.3 → NP_705815.1 ribosomal protein S6 kinase alpha-5 isoform 1

See identical proteins and their annotated locations for NP_705815.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC123705, AC159818, AK032316, AK160758, AY341873, BQ174267, CX207283

Consensus CDS

CCDS26107.1

UniProtKB/Swiss-Prot

Q8C050, Q8CI92

Related

ENSMUSP00000042987.7, ENSMUST00000043599.7

Conserved Domains (3) summary

smart00220
Location:48 → 317

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14179
Location:417 → 791

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:47 → 379

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

100514692..100691693 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516275.5 → XP_006516338.1 ribosomal protein S6 kinase alpha-5 isoform X1

Conserved Domains (2) summary

cd14179
Location:393 → 702

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:34 → 355

PKc_like; Protein Kinases, catalytic domain
XM_036157624.1 → XP_036013517.1 ribosomal protein S6 kinase alpha-5 isoform X2

Conserved Domains (2) summary

cd14179
Location:389 → 698

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:47 → 351

PKc_like; Protein Kinases, catalytic domain
XM_030246950.2 → XP_030102810.1 ribosomal protein S6 kinase alpha-5 isoform X3

UniProtKB/TrEMBL

Q3TUH8

Conserved Domains (2) summary

cd14179
Location:199 → 508

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:1 → 161

PKc_like; Protein Kinases, catalytic domain
XM_036157625.1 → XP_036013518.1 ribosomal protein S6 kinase alpha-5 isoform X3

UniProtKB/TrEMBL

Q3TUH8

Conserved Domains (2) summary

cd14179
Location:199 → 508

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:1 → 161

PKc_like; Protein Kinases, catalytic domain
XM_030246949.2 → XP_030102809.1 ribosomal protein S6 kinase alpha-5 isoform X3

UniProtKB/TrEMBL

Q3TUH8

Conserved Domains (2) summary

cd14179
Location:199 → 508

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:1 → 161

PKc_like; Protein Kinases, catalytic domain