Y45F10D.7 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y45F10D.7
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00012887
Locus tag: CELE_Y45F10D.7
See related: AllianceGenome:WB:WBGene00012887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in rRNA processing. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y45F10D.7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (13789081..13796224)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y45F10D.8 (e-PCR)
- UniSTS:305932

Y45F10D.9 (e-PCR)
- UniSTS:306554

Y45F10D.7 (e-PCR)
- UniSTS:308181

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD_REPEATS_REGION domain-containing protein

NP_001369795.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13789081..13796224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383239.2 → NP_001369795.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O62477, O62478

Conserved Domains (5) summary

COG2319
Location:499 → 680

WD40; WD40 repeat [General function prediction only]

sd00039
Location:233 → 271

7WD40; WD40 repeat [structural motif]

pfam04192
Location:701 → 920

Utp21; Utp21 specific WD40 associated putative domain

pfam12894
Location:424 → 470

ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain

cl29593
Location:152 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...