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    lsy-13 ING family member lsy-13 [ Caenorhabditis elegans ]

    Gene ID: 178470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lsy-13
    Official Full Name
    ING family member lsy-13
    Primary source
    WormBase:WBGene00020287
    Locus tag
    CELE_T06A10.4
    See related
    AllianceGenome:WB:WBGene00020287
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be located in nucleus. Orthologous to several human genes including ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lsy-13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (16863870..16865486)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methionine aminopeptidase 2 Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein Neighboring gene CHHC U11-48K-type domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49. O'Meara MM, et al. Genetics, 2010 Dec. PMID 20923973, Free PMC Article
    2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ING family member lsy-13
    NP_001367153.1
    • Confirmed by transcript evidence
    NP_001368543.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16863870..16865486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380559.1 → NP_001367153.1  ING family member lsy-13 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AXE0, A3QMD7
      Conserved Domains (1) summary
      cl22851
      Location:177 → 222
      PHD_SF; PHD finger superfamily

    2. NM_001380560.2 → NP_001368543.1  ING family member lsy-13 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG5034
      Location:74 → 150
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version

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