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    ctsa-1.2 Serine carboxypeptidase ctsa-1.2 [ Caenorhabditis elegans ]

    Gene ID: 174802, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctsa-1.2
    Official Full Name
    Serine carboxypeptidase ctsa-1.2
    Primary source
    WormBase:WBGene00008741
    Locus tag
    CELE_F13D12.6
    See related
    AllianceGenome:WB:WBGene00008741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Is expressed in intestine. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctsa-1.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11739358..11742876)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia. Radeke LJ, et al. BMC Microbiol, 2020 Jun 19. PMID 32560629, Free PMC Article
    2. Sexual dimorphism in Caenorhabditis elegans stress resistance. Piloto JH, et al. PLoS One, 2022. PMID 35951614, Free PMC Article
    3. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
    4. Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Rive C, et al. Small, 2019 Nov. PMID 31576668
    5. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine carboxypeptidase ctsa-1.2
    NP_496507.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11739358..11742876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064106.6 → NP_496507.1  Serine carboxypeptidase ctsa-1.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52715
      Conserved Domains (1) summary
      pfam00450
      Location:28 → 450
      Peptidase_S10; Serine carboxypeptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52715.1

    Gene LinkOut

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