mmaa-1 Methylmalonic aciduria type A homolog, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mmaa-1
Official Full Name: Methylmalonic aciduria type A homolog, mitochondrial
Primary source: WormBase:WBGene00020169
Locus tag: CELE_T02G5.13
See related: AllianceGenome:WB:WBGene00020169
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Used to study methylmalonic acidemia. Human ortholog(s) of this gene implicated in methylmalonic acidemia cblA type. Orthologous to human MMAA (metabolism of cobalamin associated A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mmaa-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (7099583..7101165, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T02G5.13 (e-PCR)
- UniSTS:310615

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Methylmalonic aciduria type A homolog, mitochondrial

NP_001022302.1

Confirmed by transcript evidence

NP_001379869.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7099583..7101165 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393114.1 → NP_001379869.1 Methylmalonic aciduria type A homolog, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl38936
Location:24 → 297

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001027131.7 → NP_001022302.1 Methylmalonic aciduria type A homolog, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22111, Q6AHP0

Conserved Domains (2) summary

smart00382
Location:127 → 227

AAA; ATPases associated with a variety of cellular activities

cl21455
Location:64 → 398

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases