pigw-1 Phosphatidylinositol-glycan biosynthesis class W protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pigw-1
Official Full Name: Phosphatidylinositol-glycan biosynthesis class W protein
Primary source: WormBase:WBGene00022447
Locus tag: CELE_Y110A2AL.12
See related: AllianceGenome:WB:WBGene00022447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pigw-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (2877419..2884910, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

Y110A2A_1898.e (e-PCR)
- UniSTS:323435

Y110A2A_54.a (e-PCR)
- UniSTS:324544

Y110A2A_1898.d (e-PCR)
- UniSTS:324038

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Phosphatidylinositol-glycan biosynthesis class W protein

NP_001022407.2

Confirmed by transcript evidence

NP_001367965.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

2877419..2884910 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027236.3 → NP_001022407.2 Phosphatidylinositol-glycan biosynthesis class W protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022407.2

Status: REVIEWED

UniProtKB/TrEMBL

D6RYD7

Conserved Domains (1) summary

cl02109
Location:15 → 489

GWT1; GWT1
NM_001381355.1 → NP_001367965.1 Phosphatidylinositol-glycan biosynthesis class W protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

D6RYD6

Conserved Domains (1) summary

pfam06423
Location:55 → 197

GWT1