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    vha-17 V-type proton ATPase subunit e [ Caenorhabditis elegans ]

    Gene ID: 177757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vha-17
    Official Full Name
    V-type proton ATPase subunit e
    Primary source
    WormBase:WBGene00009882
    Locus tag
    CELE_F49C12.13
    See related
    AllianceGenome:WB:WBGene00009882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development; embryonic body morphogenesis; and regulation of syncytium formation by plasma membrane fusion. Located in apical junction complex and apical plasma membrane. Is expressed in excretory cell; hypodermal cell; and intestine. Orthologous to several human genes including ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vha-17 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (9321801..9322525)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 26S proteasome non-ATPase regulatory subunit 6 Neighboring gene Methyltransferase type 11 domain-containing protein Neighboring gene Translation machinery-associated protein 7 homolog Neighboring gene DUF1648 domain-containing protein;Ribonuclease kappa Neighboring gene DUF19 domain-containing protein Neighboring gene Serine/arginine repetitive matrix protein 2-like Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Kontani K, et al. Dev Cell, 2005 May. PMID 15866168
    2. glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis. Rabbitts BM, et al. Genetics, 2008 Oct. PMID 18780725, Free PMC Article
    3. Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy. Bott LC, et al. Brain Commun, 2021. PMID 34909687, Free PMC Article
    4. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
    5. Cell fusion. Podbilewicz B. WormBook, 2006 Jan 6. PMID 18050486, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of syncytium formation by plasma membrane fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of syncytium formation by plasma membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit e
    NP_501636.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9321801..9322525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069235.10 → NP_501636.2  V-type proton ATPase subunit e [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501636.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20591
      Conserved Domains (1) summary
      pfam05493
      Location:6 → 64
      ATP_synt_H; ATP synthase subunit H
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20591.2

    Gene LinkOut

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