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    ins-3 putative insulin-like peptide beta-type 3 [ Caenorhabditis elegans ]

    Gene ID: 191684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-3
    Official Full Name
    putative insulin-like peptide beta-type 3
    Primary source
    WormBase:WBGene00002086
    Locus tag
    CELE_ZK75.3
    See related
    AllianceGenome:WB:WBGene00002086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone activity. Involved in dauer larval development and negative regulation of dauer entry. Predicted to be located in extracellular region. Is expressed in several structures, including coelomocyte; egg-laying apparatus; gonad; head muscle; and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (5990099..5990768, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative insulin-like peptide beta-type 2 Neighboring gene putative insulin-like peptide beta-type 1 Neighboring gene Putative insulin-like peptide beta-type 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin signaling promotes germline proliferation in C. elegans. Michaelson D, et al. Development, 2010 Feb. PMID 20110332, Free PMC Article
    2. Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans. Liu Z, et al. Toxics, 2024 Jun 7. PMID 38922100, Free PMC Article
    3. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585
    4. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Hung WL, et al. Development, 2014 Apr. PMID 24671950, Free PMC Article
    5. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. Hung WL, et al. EMBO J, 2013 Jun 12. PMID 23665919, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative insulin-like peptide beta-type 3
    NP_495195.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5990099..5990768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062794.9 → NP_495195.1  putative insulin-like peptide beta-type 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09628
      Conserved Domains (1) summary
      pfam03488
      Location:59 → 105
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09628.1

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