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    vrk-1 Serine/threonine-protein kinase VRK1 [ Caenorhabditis elegans ]

    Gene ID: 174004, updated on 9-Dec-2024

    Summary

    Official Symbol
    vrk-1
    Official Full Name
    Serine/threonine-protein kinase VRK1
    Primary source
    WormBase:WBGene00017895
    Locus tag
    CELE_F28B12.3
    See related
    AllianceGenome:WB:WBGene00017895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase activity. Involved in several processes, including cell fate specification; gonad development; and regulation of fibroblast growth factor receptor signaling pathway. Located in chromatin and nuclear envelope. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to several human genes including VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See vrk-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5921967..5924838)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Frataxin, mitochondrial Neighboring gene Tyrosine-protein phosphatase non-receptor type ptp-2 Neighboring gene ncRNA Neighboring gene TEA domain-containing protein;Transcription enhancer factor-like protein egl-44 Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Serine/threonine-protein kinase VRK1
    NP_495185.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5921967..5924838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062784.8NP_495185.1  Serine/threonine-protein kinase VRK1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19848
      Conserved Domains (2) summary
      COG0515
      Location:32415
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14015
      Location:26312
      STKc_VRK; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase