amx-1 Lysine-specific histone demethylase 1B homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: amx-1
Official Full Name: Lysine-specific histone demethylase 1B homolog
Primary source: WormBase:WBGene00000137
Locus tag: CELE_R13G10.2
See related: AllianceGenome:WB:WBGene00000137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in chemosensory neurons. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See amx-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (3822403..3826260)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
Title: Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13G10.3 (e-PCR)
- UniSTS:319586

R13G10.2 (e-PCR)
- UniSTS:321648

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IEA Inferred from Electronic Annotation more info
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Lysine-specific histone demethylase 1B homolog

NP_497772.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3822403..3826260

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065371.7 → NP_497772.2 Lysine-specific histone demethylase 1B homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497772.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21988

Conserved Domains (3) summary

pfam01593
Location:361 → 813

Amino_oxidase; Flavin containing amine oxidoreductase

pfam04433
Location:251 → 337

SWIRM; SWIRM domain

pfam13450
Location:356 → 414

NAD_binding_8; NAD(P)-binding Rossmann-like domain