gly-8 putative N-acetylgalactosaminyltransferase 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gly-8
Official Full Name: putative N-acetylgalactosaminyltransferase 8
Primary source: WormBase:WBGene00001633
Locus tag: CELE_Y66A7A.6
See related: AllianceGenome:WB:WBGene00001633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation and regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11) and GALNTL5 (polypeptide N-acetylgalactosaminyltransferase like 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gly-8 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (11625242..11628235)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C37G2.6 (e-PCR)
- UniSTS:313825

Y66A7A.6 (e-PCR)
- UniSTS:318690

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative N-acetylgalactosaminyltransferase 8

NP_001366981.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11625242..11628235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379936.3 → NP_001366981.1 putative N-acetylgalactosaminyltransferase 8 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O45293

Conserved Domains (1) summary

cd02510
Location:110 → 410

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans