catp-6 Cation-transporting ATPase 13A3;Cation-transporting P-type ATPase N-terminal domain-containing protein;putative cation-transporting ATPase W08D2.5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: catp-6
Official Full Name: Cation-transporting ATPase 13A3;Cation-transporting P-type ATPase N-terminal domain-containing protein;putative cation-transporting ATPase W08D2.5
Primary source: WormBase:WBGene00012341
Locus tag: CELE_W08D2.5
See related: AllianceGenome:WB:WBGene00012341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in protein folding. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including egg-laying apparatus; germ line; gonad; pharynx; and somatic gonad precursor. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See catp-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 21

Sequence:: Chromosome: IV; NC_003282.8 (9817412..9824580, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Title: ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
CATP-6 probably acts as a non-essential upstream positive regulator of GEM-1
Title: CATP-6, a C. elegans ortholog of ATP13A2 PARK9, positively regulates GEM-1, an SLC16A transporter.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08D2.6 (e-PCR)
- UniSTS:306552

W08D2.5 (e-PCR)
- UniSTS:308163

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables polyamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Cation-transporting ATPase 13A3;Cation-transporting P-type ATPase N-terminal domain-containing protein;putative cation-transporting ATPase W08D2.5

NP_001255430.2

Confirmed by transcript evidence

NP_001255431.1

Confirmed by transcript evidence

NP_001255432.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9817412..9824580 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268501.2 → NP_001255430.2 putative cation-transporting ATPase W08D2.5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27533

Conserved Domains (1) summary

TIGR01657
Location:18 → 1137

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
NM_001268502.3 → NP_001255431.1 Cation-transporting P-type ATPase N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255431.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27533

UniProtKB/TrEMBL

F5GUA7

Conserved Domains (6) summary

TIGR01657
Location:1 → 1077

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:163 → 404

E1-E2_ATPase; E1-E2 ATPase

pfam00690
Location:97 → 153

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:532 → 587

Cation_ATPase; Cation transport ATPase (P-type)

cl02929
Location:900 → 1081

Cation_ATPase_C; Cation transporting ATPase, C-terminus

cl21460
Location:806 → 885

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001268503.3 → NP_001255432.1 Cation-transporting ATPase 13A3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255432.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT44

Conserved Domains (4) summary

pfam00122
Location:2 → 90

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:218 → 273

Cation_ATPase; Cation transport ATPase (P-type)

cl02929
Location:586 → 767

Cation_ATPase_C; Cation transporting ATPase, C-terminus

cl21460
Location:492 → 571

HAD_like; Haloacid Dehalogenase-like Hydrolases