mec-15 F-box/WD repeat-containing protein mec-15 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-15
Official Full Name: F-box/WD repeat-containing protein mec-15
Primary source: WormBase:WBGene00003177
Locus tag: CELE_T01E8.4
See related: AllianceGenome:WB:WBGene00003177
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of GABAergic synaptic transmission; and positive regulation of nervous system process. Located in perikaryon. Is expressed in neurons and spermatheca. Orthologous to human FBXW9 (F-box and WD repeat domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mec-15 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (10236936..10239695, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans.
Title: Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01E8.4 (e-PCR)
- UniSTS:307890

T01E8.6 (e-PCR)
- UniSTS:318392

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle targeting	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein mec-15

NP_496207.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10236936..10239695 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063806.7 → NP_496207.1 F-box/WD repeat-containing protein mec-15 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496207.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22071

Conserved Domains (3) summary

sd00039
Location:106 → 154

7WD40; WD40 repeat [structural motif]

pfam12937
Location:9 → 52

F-box-like; F-box-like

cl25539
Location:88 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...