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    sek-6 mitogen-activated protein kinase kinase [ Caenorhabditis elegans ]

    Gene ID: 189074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sek-6
    Official Full Name
    mitogen-activated protein kinase kinase
    Primary source
    WormBase:WBGene00012162
    Locus tag
    CELE_VZC374L.1
    See related
    AllianceGenome:WB:WBGene00012162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable JUN kinase kinase activity. Predicted to be involved in MAPK cascade. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sek-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (10031150..10033284)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene Peptidase_M13 domain-containing protein Neighboring gene ncRNA Neighboring gene MAP kinase kinase mkk-4 Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
    2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase
    NP_001391086.1
    • Confirmed by transcript evidence
    NP_509683.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10031150..10033284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077282.4 → NP_509683.1  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01706
      Conserved Domains (1) summary
      cl21453
      Location:57 → 343
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001404204.1 → NP_001391086.1  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9MJ97
    Nucleotide Protein
    Heading Accession and Version

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