U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    plk-3 Serine/threonine-protein kinase plk-3 [ Caenorhabditis elegans ]

    Gene ID: 266900, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    plk-3
    Official Full Name
    Serine/threonine-protein kinase plk-3
    Primary source
    WormBase:WBGene00004044
    Locus tag
    CELE_F55G1.8
    See related
    AllianceGenome:WB:WBGene00004044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic spindle organization. Predicted to be active in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See plk-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (7470860..7473209, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PA14 domain-containing protein Neighboring gene F-box C protein Neighboring gene ncRNA Neighboring gene RING-CH-type domain-containing protein Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene Putative pyrroline-5-carboxylate reductase 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans contains a third polo-like kinase gene. Chase D, et al. DNA Seq, 2000. PMID 11092748
    2. DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells. Spike CA, et al. Development, 2008 Mar. PMID 18234720, Free PMC Article
    3. Reference quantitative transcriptome dataset for adult Caenorhabditis elegans. Piovesan A, et al. Data Brief, 2019 Aug. PMID 31440537, Free PMC Article
    4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine-protein kinase plk-3
    NP_501196.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7470860..7473209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068795.7 → NP_501196.1  Serine/threonine-protein kinase plk-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20845
      Conserved Domains (4) summary
      smart00220
      Location:35 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:499 → 579
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:390 → 474
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:35 → 286
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20845.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools