U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    F14B4.1 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172750, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    F14B4.1
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00008779
    Locus tag
    CELE_F14B4.1
    See related
    AllianceGenome:WB:WBGene00008779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See F14B4.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (9265951..9271058, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Sushi domain-containing protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene Phosphotransferase Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    EGF-like domain-containing protein
    NP_492474.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9265951..9271058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060073.8 → NP_492474.2  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492474.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK8
      Conserved Domains (5) summary
      smart00135
      Location:470 → 512
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:663 → 698
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:448 → 486
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:588 → 618
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:272 → 313
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.