T24H10.1 Putative transcription elongation factor S-II [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T24H10.1
Official Full Name: Putative transcription elongation factor S-II
Primary source: WormBase:WBGene00012000
Locus tag: CELE_T24H10.1
See related: AllianceGenome:WB:WBGene00012000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anal depressor muscle; body wall musculature; nervous system; pharynx; and reproductive system. Orthologous to several human genes including TCEA1 (transcription elongation factor A1); TCEA2 (transcription elongation factor A2); and TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T24H10.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (9099371..9100569)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T24H10.1 (e-PCR)
- UniSTS:308108

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative transcription elongation factor S-II

NP_495941.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9099371..9100569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063540.3 → NP_495941.1 Putative transcription elongation factor S-II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495941.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52652

Conserved Domains (4) summary

smart00510
Location:146 → 246

TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)

smart00509
Location:8 → 83

TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)

cd13749
Location:261 → 307

Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS

TIGR01385
Location:4 → 308

TFSII; transcription elongation factor S-II