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    smc-4 Structural maintenance of chromosomes protein 4 [ Caenorhabditis elegans ]

    Gene ID: 175603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smc-4
    Official Full Name
    Structural maintenance of chromosomes protein 4
    Primary source
    WormBase:WBGene00004874
    Locus tag
    CELE_F35G12.8
    See related
    AllianceGenome:WB:WBGene00004874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in mitotic sister chromatid segregation and positive regulation of nematode male tail tip morphogenesis. Located in chromosome, centromeric region and condensed chromosome. Is expressed in head; intestine; linker cell; and tail. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smc-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (4587501..4593124)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 26S proteasome non-ATPase regulatory subunit 5 Neighboring gene GUN4 domain-containing protein;Ras-associating domain-containing protein;SPK domain-containing protein Neighboring gene Divalent-cation tolerance protein CutA Neighboring gene Enhancer of rudimentary homolog 2 Neighboring gene Anaphase-promoting complex subunit 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay. Maddox PS, et al. Proc Natl Acad Sci U S A, 2006 Oct 10. PMID 17005720, Free PMC Article
    2. SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes. Pferdehirt RR, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043781, Free PMC Article
    3. C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. Hagstrom KA, et al. Genes Dev, 2002 Mar 15. PMID 11914278, Free PMC Article
    4. An SMC-like protein binds and regulates Caenorhabditis elegans condensins. Chao LF, et al. PLoS Genet, 2017 Mar. PMID 28301465, Free PMC Article
    5. A highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms. Ma H, et al. Mol Cell Proteomics, 2012 Aug. PMID 22474084, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes protein 4
    NP_497935.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4587501..4593124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065534.8 → NP_497935.1  Structural maintenance of chromosomes protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20060
      Conserved Domains (4) summary
      cd03274
      Location:1261 → 1362
      ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
      pfam02463
      Location:91 → 1361
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam06470
      Location:618 → 734
      SMC_hinge; SMC proteins Flexible Hinge Domain
      cl23763
      Location:865 → 1037
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20060.1

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