sod-1 Superoxide dismutase [Cu-Zn] [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sod-1
Official Full Name: Superoxide dismutase [Cu-Zn]
Primary source: WormBase:WBGene00004930
Locus tag: CELE_C15F1.7
See related: AllianceGenome:WB:WBGene00004930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables copper ion binding activity; protein homodimerization activity; and superoxide dismutase activity. Involved in regulation of brood size; regulation of vulval development; and removal of superoxide radicals. Located in cytosol and mitochondrion. Is expressed in several structures, including somatic gonad and somatic nervous system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sod-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (6972706..6973887, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We found that guanylyl cyclases GCY-5 and GCY-22 and neuropeptide receptor NPR-1 act antagonistically to regulate SOD-1 expression in the gustatory neuron ASER.
Title: Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis.
These data suggest that SOD1 mutants are removed from the nucleus by CRM1 as a defense mechanism against proteotoxicity of misfolded SOD1 in the nucleus.
Title: Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus.
a post-translational modification to the inactive enzyme during hypoxia
Title: Post-translational modification of Cu/Zn superoxide dismutase under anaerobic conditions.
this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria.
Title: SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation.
SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.
Title: SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.
the ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans
Title: An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.
although several long-lived mutants of Caenorhabditis elegans have increased SOD levels, this phenomenon does not correlate with life span or growth rate.
Title: A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
the C. elegans intracellular CuZn-SODs (wSOD-1 and wSOD-5) are not dependent on the copper chaperone CCS for activation
Title: Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15F1.b (e-PCR)
- UniSTS:322493

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Superoxide dismutase [Cu-Zn]

NP_001021956.1

Confirmed by transcript evidence

NP_001021957.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6972706..6973887 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026785.4 → NP_001021956.1 Superoxide dismutase [Cu-Zn] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021956.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34697, Q5W7E8, Q9N5Y1

Conserved Domains (1) summary

cd00305
Location:26 → 171

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
NM_001026786.5 → NP_001021957.1 Superoxide dismutase [Cu-Zn] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021957.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34697

Conserved Domains (1) summary

cd00305
Location:4 → 149

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...