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    ran-4 putative nuclear transport factor 2 [ Caenorhabditis elegans ]

    Gene ID: 172648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ran-4
    Official Full Name
    putative nuclear transport factor 2
    Primary source
    WormBase:WBGene00004305
    Locus tag
    CELE_R05D11.3
    See related
    AllianceGenome:WB:WBGene00004305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be part of nuclear pore central transport channel. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ran-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (8591215..8591978)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase Neighboring gene Smad protein daf-8 Neighboring gene Transmembrane protein 208 Neighboring gene Sphingomyelin phosphodiesterase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
    2. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Garrido-Lecca A, et al. Mol Cell Biol, 2010 Aug. PMID 20498277, Free PMC Article
    3. Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. Ha MK, et al. Proteomics, 2006 Jun. PMID 16673436
    4. Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1. Huang S, et al. Development, 2007 Jul. PMID 17567664
    5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative nuclear transport factor 2
    NP_492322.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8591215..8591978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059921.5 → NP_492322.1  putative nuclear transport factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21735
      Conserved Domains (1) summary
      cd00780
      Location:6 → 128
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21735.1

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