gcy-35 Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gcy-35
Official Full Name: Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35
Primary source: WormBase:WBGene00001555
Locus tag: CELE_T04D3.4
See related: AllianceGenome:WB:WBGene00001555
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including carbon monoxide binding activity; nitric oxide binding activity; and oxygen binding activity. Involved in several processes, including aerotaxis; cGMP-mediated signaling; and response to hyperoxia. Located in dendrite and neuronal cell body. Is expressed in body wall musculature; neurons; and pharyngeal muscle cell. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcy-35 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 17

Sequence:: Chromosome: I; NC_003279.8 (13325230..13333513)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

joint loss of function of gcy-35 and npr-1 extends lifespan through reactive oxygen species signaling.
Title: Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans.
The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants
Title: Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
Social feeding and related behaviors occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity; GCY-35 is regulated by molecular oxygen
Title: Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04D3.5 (e-PCR)
- UniSTS:306079

T04D3.4 (e-PCR)
- UniSTS:318406

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables carbon monoxide binding	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen sensor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in aerotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35

NP_001252131.1

Confirmed by transcript evidence

NP_001252133.1

Confirmed by transcript evidence

NP_001252134.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13325230..13333513

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001265202.3 → NP_001252131.1 Soluble guanylate cyclase gcy-35 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252131.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02298

Conserved Domains (4) summary

smart00044
Location:388 → 579

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:415 → 599

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:3 → 167

HNOB; Haem-NO-binding

pfam07701
Location:218 → 409

HNOBA; Heme NO binding associated
NM_001265204.3 → NP_001252133.1 Guanylate cyclase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252133.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2G5

Conserved Domains (1) summary

smart00044
Location:1 → 141

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
NM_001265205.3 → NP_001252134.1 Guanylate cyclase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252134.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2G4

Conserved Domains (1) summary

cl11967
Location:1 → 49

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases