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    alh-8 putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-8
    Official Full Name
    putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
    Primary source
    WormBase:WBGene00000114
    Locus tag
    CELE_F13D12.4
    See related
    AllianceGenome:WB:WBGene00000114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity. Predicted to be involved in thymine catabolic process and valine catabolic process. Located in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11729055..11731198)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene L-lactate dehydrogenase Neighboring gene Transmembrane protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene Serine carboxypeptidase ctsa-1.2 Neighboring gene Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Watson E, et al. Elife, 2016 Jul 6. PMID 27383050, Free PMC Article
    2. C. elegans as a model for inter-individual variation in metabolism. Fox BW, et al. Nature, 2022 Jul. PMID 35794472, Free PMC Article
    3. Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans. Goh GYS, et al. G3 (Bethesda), 2023 Jun 1. PMID 37075089, Free PMC Article
    4. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables malonate-semialdehyde dehydrogenase (acetylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thymine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thymine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
    NP_001022078.1
    • Confirmed by transcript evidence
    NP_001022079.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11729055..11731198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026907.5 → NP_001022078.1  putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52713
      Conserved Domains (2) summary
      cd07085
      Location:30 → 506
      ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
      PLN02466
      Location:18 → 502
      PLN02466; aldehyde dehydrogenase family 2 member

    2. NM_001026908.7 → NP_001022079.1  putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMI1
      Conserved Domains (1) summary
      cl11961
      Location:30 → 87
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52713.1

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