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    aco-1 Cytoplasmic aconitate hydratase [ Caenorhabditis elegans ]

    Gene ID: 181324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aco-1
    Official Full Name
    Cytoplasmic aconitate hydratase
    Primary source
    WormBase:WBGene00000040
    Locus tag
    CELE_ZK455.1
    See related
    AllianceGenome:WB:WBGene00000040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables aconitate hydratase activity. Involved in tricarboxylic acid metabolic process. Located in cytosol. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aco-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (11339874..11343327)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Galanin-like G-protein coupled receptor npr-9 Neighboring gene Receptor-type guanylate cyclase gcy-9 Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Multidrug resistance protein pgp-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans. Gourley BL, et al. J Biol Chem, 2003 Jan 31. PMID 12438312
    2. Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C.elegans. Kim YI, et al. J Mol Biol, 2004 Sep 10. PMID 15327944
    3. Shigella flexneri infection in Caenorhabditis elegans: cytopathological examination and identification of host responses. George DT, et al. PLoS One, 2014. PMID 25187942, Free PMC Article
    4. An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics. Shaver AO, et al. Front Mol Biosci, 2022. PMID 36438654, Free PMC Article
    5. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Zhang L, et al. Mol Cell, 2007 Nov 30. PMID 18042455, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. biochemical characterization and regulation
      Title: Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cytoplasmic aconitate hydratase
    NP_509898.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11339874..11343327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077497.4 → NP_509898.1  Cytoplasmic aconitate hydratase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23500
      Conserved Domains (3) summary
      cd01586
      Location:80 → 565
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:668 → 835
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3 → 887
      PTZ00092; aconitate hydratase-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23500.1

    Gene LinkOut

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