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    • Showing Current items.

    lonp-2 Lon protease homolog 2, peroxisomal [ Caenorhabditis elegans ]

    Gene ID: 176643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lonp-2
    Official Full Name
    Lon protease homolog 2, peroxisomal
    Primary source
    WormBase:WBGene00013541
    Locus tag
    CELE_Y75B8A.4
    See related
    AllianceGenome:WB:WBGene00013541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activity. Predicted to be involved in protein processing and protein targeting to peroxisome. Predicted to be located in peroxisome. Predicted to be active in peroxisomal matrix. Is expressed in intestine. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lonp-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (12107774..12113468)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lon protease homolog 2, peroxisomal
    NP_499577.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12107774..12113468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067176.5 → NP_499577.1  Lon protease homolog 2, peroxisomal [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XW87
      Conserved Domains (6) summary
      smart00464
      Location:8 → 75
      LON; Found in ATP-dependent protease La (LON)
      COG0466
      Location:1 → 760
      Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:332 → 474
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam07106
      Location:149 → 261
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      cl21455
      Location:297 → 354
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl21678
      Location:591 → 760
      ChlI; Subunit ChlI of Mg-chelatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW87.1

    Gene LinkOut

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