F47B7.2 Sulfhydryl oxidase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F47B7.2
Official Full Name: Sulfhydryl oxidase
Primary source: WormBase:WBGene00018533
Locus tag: CELE_F47B7.2
See related: AllianceGenome:WB:WBGene00018533
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in membrane. Predicted to be active in Golgi membrane and extracellular space. Is expressed in several structures, including body wall musculature; hypodermis; intestine; non-striated muscle; and pharynx. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F47B7.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (3772762..3778081)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F47B7.2 (e-PCR)
- UniSTS:314364

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables flavin-dependent sulfhydryl oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin-dependent sulfhydryl oxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiol oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sulfhydryl oxidase

NP_001370700.1

Confirmed by transcript evidence

NP_508653.1

Confirmed by transcript evidence

NP_508654.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3772762..3778081

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076252.8 → NP_508653.1 Sulfhydryl oxidase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508653.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95QF9

Conserved Domains (3) summary

cd02992
Location:48 → 161

PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...

pfam04777
Location:420 → 514

Evr1_Alr; Erv1 / Alr family

cl04793
Location:357 → 391

PSRP-3_Ycf65; Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)
NM_001383550.2 → NP_001370700.1 Sulfhydryl oxidase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KZY5

Conserved Domains (3) summary

cd02992
Location:48 → 161

PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...

pfam04777
Location:420 → 515

Evr1_Alr; Erv1 / Alr family

pfam18371
Location:317 → 410

FAD_SOX; Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase
NM_076253.6 → NP_508654.1 Sulfhydryl oxidase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508654.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20514

Conserved Domains (3) summary

cd02992
Location:48 → 161

PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...

pfam04777
Location:420 → 514

Evr1_Alr; Erv1 / Alr family

cl04793
Location:357 → 391

PSRP-3_Ycf65; Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)