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    Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 14426, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galnt4provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 4provided by MGI
    Primary source
    MGI:MGI:894692
    See related
    Ensembl:ENSMUSG00000090035 AllianceGenome:MGI:894692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including exocrine system; extraembryonic component; gut; and skeleton. Orthologous to several human genes including GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Galnt4 in Genome Data Viewer
    Location:
    10 51.06 cM; 10 C3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98943997..98949109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99108135..99113247)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:98376846-98377147 Neighboring gene predicted gene, 53607 Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene STARR-positive B cell enhancer ABC_E3912 Neighboring gene STARR-seq mESC enhancer starr_27702 Neighboring gene STARR-seq mESC enhancer starr_27703 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98589429-98589538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98590442-98590625 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98594927-98595144 Neighboring gene POC1 centriolar protein B Neighboring gene STARR-seq mESC enhancer starr_27706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98634758-98634867 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98644928-98645081 Neighboring gene STARR-positive B cell enhancer ABC_E6916 Neighboring gene predicted gene 16239 Neighboring gene STARR-positive B cell enhancer mm9_chr10:98667182-98667482 Neighboring gene STARR-seq mESC enhancer starr_27708 Neighboring gene predicted gene, 34574

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked glycosylation via serine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein O-linked glycosylation via threonine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 4
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4
    galNAc-T4
    polypeptide GalNAc transferase 4
    pp-GaNTase 4
    ppGaNTase-T4
    protein-UDP acetylgalactosaminyltransferase 4
    NP_056552.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015737.4NP_056552.1  polypeptide N-acetylgalactosaminyltransferase 4

      See identical proteins and their annotated locations for NP_056552.1

      Status: VALIDATED

      Source sequence(s)
      AK148036, AV080565, BP761617, BQ179479, CJ093518
      Consensus CDS
      CCDS48679.1
      UniProtKB/Swiss-Prot
      O08832, Q3U681
      Related
      ENSMUSP00000125315.3, ENSMUST00000161240.4
      Conserved Domains (4) summary
      cd02510
      Location:138432
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:133430
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:446576
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:446574
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      98943997..98949109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)