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    Csl citrate synthase like [ Mus musculus (house mouse) ]

    Gene ID: 71832, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cslprovided by MGI
    Official Full Name
    citrate synthase likeprovided by MGI
    Primary source
    MGI:MGI:1919082
    See related
    Ensembl:ENSMUSG00000046934 AllianceGenome:MGI:1919082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700007H16Rik
    Summary
    Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Csl in Genome Data Viewer
    Location:
    10 D1; 10 51.2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99593567..99595346, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99757705..99759658, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20110 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene predicted gene, 35101 Neighboring gene STARR-seq mESC enhancer starr_27728 Neighboring gene predicted gene, 35206 Neighboring gene STARR-seq mESC enhancer starr_27729 Neighboring gene predicted gene, 35437

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables citrate (Si)-synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    citrate synthase-like protein
    NP_082221.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027945.4NP_082221.2  citrate synthase-like protein

      Status: VALIDATED

      Source sequence(s)
      AC158633
      Consensus CDS
      CCDS24149.1
      UniProtKB/TrEMBL
      Q80X68, Q9DAM4
      Related
      ENSMUSP00000052373.5, ENSMUST00000056085.6
      Conserved Domains (2) summary
      cd06105
      Location:33459
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:29459
      PLN02456; citrate synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      99593567..99595346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)