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    Mettl25 methyltransferase like 25 [ Mus musculus (house mouse) ]

    Gene ID: 216292, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mettl25provided by MGI
    Official Full Name
    methyltransferase like 25provided by MGI
    Primary source
    MGI:MGI:3041259
    See related
    Ensembl:ENSMUSG00000036009 AllianceGenome:MGI:3041259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Is expressed in adrenal gland; ganglia; telencephalon; and testis. Orthologous to human METTL25 (methyltransferase like 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mettl25 in Genome Data Viewer
    Location:
    10 D1; 10 55.12 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (105599052..105677246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (105763185..105841380, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane and tetratricopeptide repeat containing 2 Neighboring gene keratin 19 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:105012433-105012734 Neighboring gene predicted gene 15663 Neighboring gene STARR-seq mESC enhancer starr_27763 Neighboring gene STARR-seq mESC enhancer starr_27765 Neighboring gene STARR-positive B cell enhancer ABC_E9803 Neighboring gene STARR-positive B cell enhancer ABC_E6919 Neighboring gene coiled-coil domain containing 59 Neighboring gene STARR-seq mESC enhancer starr_27766 Neighboring gene STARR-seq mESC enhancer starr_27767 Neighboring gene predicted gene, 25342

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    probable methyltransferase-like protein 25
    Names
    methyltransferase-like protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359640.1NP_001346569.1  probable methyltransferase-like protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK148535, AV286383, BB345676, BC067068, CK618051
      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001359642.1NP_001346571.1  probable methyltransferase-like protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK148535, AV286383, BC067068, CK618051
      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_207522.3NP_997405.3  probable methyltransferase-like protein 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125108, AC132471
      Consensus CDS
      CCDS36049.2
      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      UniProtKB/TrEMBL
      A0A0R4J0G2
      Related
      ENSMUSP00000038665.11, ENSMUST00000046638.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      105599052..105677246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245038.2XP_030100898.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_030245037.1XP_030100897.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_017313903.2XP_017169392.1  probable methyltransferase-like protein 25 isoform X3

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149385
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_030245039.1XP_030100899.1  probable methyltransferase-like protein 25 isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:4240
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_036155757.1XP_036011650.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. XM_030245031.1XP_030100891.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    7. XM_030245033.1XP_030100893.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    8. XM_030245032.1XP_030100892.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    9. XM_011243412.3XP_011241714.1  probable methyltransferase-like protein 25 isoform X2

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149385
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    10. XM_011243411.3XP_011241713.1  probable methyltransferase-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149413
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    11. XM_011243414.3XP_011241716.1  probable methyltransferase-like protein 25 isoform X4

      See identical proteins and their annotated locations for XP_011241716.1

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    12. XM_030245035.1XP_030100895.1  probable methyltransferase-like protein 25 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:4240
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    13. XM_036155756.1XP_036011649.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    14. XM_036155755.1XP_036011648.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    15. XM_017313904.1XP_017169393.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_004936162.1 RNA Sequence

    2. XR_001779503.2 RNA Sequence

    3. XR_004936161.1 RNA Sequence

      Related
      ENSMUST00000176924.8
    4. XR_003948672.1 RNA Sequence

    5. XR_001779504.2 RNA Sequence

    6. XR_004936163.1 RNA Sequence

    7. XR_004936165.1 RNA Sequence

    8. XR_004936164.1 RNA Sequence

    9. XR_871710.3 RNA Sequence

    10. XR_003948673.1 RNA Sequence

    11. XR_871709.3 RNA Sequence