Nmur2 neuromedin U receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmur2provided by MGI
Official Full Name: neuromedin U receptor 2provided by MGI
Primary source: MGI:MGI:2441765
See related: Ensembl:ENSMUSG00000037393 AllianceGenome:MGI:2441765
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nmu2r
Summary: Enables neuropeptide receptor activity. Acts upstream of or within several processes, including grooming behavior; neuropeptide signaling pathway; and reduction of food intake in response to dietary excess. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 1.4), subcutaneous fat pad adult (RPKM 1.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 33.39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55915816..55931813, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (56024990..56040987, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
Title: Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Neuromedin U (NMU) regulates osteoblast differentiation and activity.
Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
Title: Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.
Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
Title: Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus.
Title: Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.
molecular basis of the NMU2R regulation of food intake and body weight in mice
Title: Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
Title: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.
Title: Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit64 (e-PCR), detects polymorphism
- UniSTS:126610

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables neuromedin U binding	IEA Inferred from Electronic Annotation more info
enables neuromedin U binding	ISO Inferred from Sequence Orthology more info
enables neuromedin U receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin U receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reduction of food intake in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-U receptor 2

Names: NMU-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153079.4 → NP_694719.2 neuromedin-U receptor 2

See identical proteins and their annotated locations for NP_694719.2

Status: PROVISIONAL

Source sequence(s)

AL671969

Consensus CDS

CCDS24716.1

UniProtKB/Swiss-Prot

Q8BZ39, Q91Z76

UniProtKB/TrEMBL

B2RPU9

Related

ENSMUSP00000044718.3, ENSMUST00000037682.3

Conserved Domains (2) summary

pfam00001
Location:54 → 319

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:48 → 333

7tm_4; Olfactory receptor