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    DEXI Dexi homolog [ Homo sapiens (human) ]

    Gene ID: 28955, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DEXIprovided by HGNC
    Official Full Name
    Dexi homologprovided by HGNC
    Primary source
    HGNC:HGNC:13267
    See related
    Ensembl:ENSG00000182108 MIM:617901; AllianceGenome:HGNC:13267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYLE
    Expression
    Ubiquitous expression in adrenal (RPKM 14.1), heart (RPKM 12.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DEXI in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10928891..10942468, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10964866..10978445, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11022748..11036325, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor 1, cytosolic Neighboring gene NANOG hESC enhancer GRCh37_chr16:10883659-10884197 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:10932437-10932956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10391 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:10964767-10965966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10399 Neighboring gene class II major histocompatibility complex transactivator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10406 Neighboring gene Sharpr-MPRA regulatory region 12638 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11066007-11066184 Neighboring gene C-type lectin domain containing 16A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11073759-11074260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11074261-11074760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7196 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11099817-11100053 Neighboring gene NANOG hESC enhancer GRCh37_chr16:11101530-11102234 Neighboring gene Sharpr-MPRA regulatory region 10204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11144189-11144765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11144766-11145343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10407 Neighboring gene ribosomal protein L7 pseudogene 46 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10412 Neighboring gene Sharpr-MPRA regulatory region 12604 Neighboring gene uncharacterized LOC105371081

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway. Dos Santos RS, et al. Diabetologia, 2019 Mar. PMID 30478640
    2. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Davison LJ, et al. Hum Mol Genet, 2012 Jan 15. PMID 21989056, Free PMC Article
    3. Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer. Miyaki Y, et al. Int J Oncol, 2012 Jan. PMID 21901246
    4. Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. Tomlinson MJ 4th, et al. Diabetes, 2014 Dec. PMID 25008175, Free PMC Article
    5. Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. Edgar AJ, et al. Am J Respir Cell Mol Biol, 2001 Jul. PMID 11472984

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations support DEXI as the aetiological gene in the type 1 diabetes-associated 16p13 genomic region, and provide the first indication of a link between this candidate gene and the regulation of local antiviral immune responses in beta cells.
      Title: DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway.
    2. Reduced DEXI mRNA level was associated with type 1 diabetes risk alleles of CLEC16A.
      Title: Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.
    3. The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI.
      Title: Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
    4. DEXI is an unappreciated autoimmune disease candidate gene, and illustrate the power of the 3C approach in progressing from genome-wide association studies results to candidate causal genes
      Title: Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.
    5. Silencing of DEXI leads to drug resistance in colon cancer.
      Title: Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dexamethasone-induced protein
    Names
    dexamethasone-induced transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014015.4 → NP_054734.2  dexamethasone-induced protein

      See identical proteins and their annotated locations for NP_054734.2

      Status: VALIDATED

      Source sequence(s)
      AC133065, BC037569
      Consensus CDS
      CCDS10545.1
      UniProtKB/Swiss-Prot
      B2RAA7, O95424
      Related
      ENSP00000330509.4, ENST00000331808.5
      Conserved Domains (1) summary
      pfam15198
      Location:1 → 95
      Dexa_ind; Dexamethasone-induced

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      10928891..10942468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      10964866..10978445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95424.2 GenPept UniProtKB/Swiss-Prot:O95424

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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