Mex3c mex3 RNA binding family member C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mex3cprovided by MGI
Official Full Name: mex3 RNA binding family member Cprovided by MGI
Primary source: MGI:MGI:2652843
See related: Ensembl:ENSMUSG00000037253 AllianceGenome:MGI:2652843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rkhd2; BM-013; A130001D14Rik
Summary: Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Acts upstream of or within chondrocyte hypertrophy; energy homeostasis; and regulation of fat cell differentiation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human MEX3C (mex-3 RNA binding family member C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 12.1), CNS E11.5 (RPKM 9.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 49.29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (73705710..73725649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (73572637..73592578)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEX3C induces cognitive impairment in mice through autophagy inhibition.
Title: MEX3C induces cognitive impairment in mice through autophagy inhibition.
Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS Expression in Hypothalamic Nuclei and Observe Morphological Differences in Embryonic Neural Tube Development.
Title: Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS Expression in Hypothalamic Nuclei and Observe Morphological Differences in Embryonic Neural Tube Development.
Mex3c mutation affects lactation through impairing milk ejection in female mice.
Title: Mex3c mutation affects lactation through impairing milk ejection in female mice.
MEX3C associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C or AP-2 complex substantially decreased exosomal but not cellular microRNA miR-451a expression
Title: MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.
The specific expression of this long MEX3C isoform in oocytes and its ability to enhance FOS mRNA nuclear export and stability all suggest that MEX3C(659AA) is an RNA-binding protein that preserves maternal FOS mRNA in oocytes.
Title: Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA.
Data indicate that Mex3c mutation significantly increases physical activity.
Title: Mex3c mutation reduces adiposity partially through increasing physical activity.
MEX3C is required for cytokine production after infection with RNA viruses that are detected by RIG-I.
Title: Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Mex3c mutation caused leanness in both heterozygous and homozygous transgenic mice, as well as a more beneficial blood glucose and lipid profile in homozygous transgenic mice, in both sexes; data show Mex3c is involved in energy balance regulation
Title: Mex3c mutation reduces adiposity and increases energy expenditure.
data suggest that MEX3C plays an important role in enhancing the translation of Igf1 mRNA directly or indirectly and promoting postnatal growth
Title: Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237841

NoName (e-PCR)
- UniSTS:237845

NIB1810 (e-PCR)
- UniSTS:48557

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chondrocyte hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding E3 ubiquitin-protein ligase MEX3C

Names: RING finger and KH domain-containing protein 2; RING-type E3 ubiquitin transferase MEX3C; RNA-binding protein MEX3C; mex3 homolog C; ring finger and KH domain containing 2

NP_001034303.3

EC 2.3.2.27

XP_011245234.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039214.4 → NP_001034303.3 RNA-binding E3 ubiquitin-protein ligase MEX3C

See identical proteins and their annotated locations for NP_001034303.3

Status: VALIDATED

Source sequence(s)

BB618103, BC108422, BC125427, BY595095, CJ067036, CJ071688

Consensus CDS

CCDS50318.1

UniProtKB/Swiss-Prot

Q05A36, Q2VPQ2

Related

ENSMUSP00000089463.5, ENSMUST00000091852.5

Conserved Domains (3) summary

smart00322
Location:319 → 384

KH; K homology RNA-binding domain

cd00105
Location:226 → 287

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam13920
Location:601 → 646

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)