Pnliprp1 pancreatic lipase related protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pnliprp1provided by MGI
Official Full Name: pancreatic lipase related protein 1provided by MGI
Primary source: MGI:MGI:97723
See related: Ensembl:ENSMUSG00000042179 AllianceGenome:MGI:97723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plrp1
Summary: Predicted to enable calcium ion binding activity and lipase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 301.3), spleen adult (RPKM 164.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 54.49 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (58717319..58732601)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (58728887..58744169)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose that PLRP1 may function as a metabolic inhibitor in vivo of pancreatic triglyceride lipase-colipase-mediated dietary triglyceride digestion.
Title: Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive pancreatic lipase-related protein 1

Names: PL-RP1

NP_061362.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018874.2 → NP_061362.1 inactive pancreatic lipase-related protein 1 precursor

See identical proteins and their annotated locations for NP_061362.1

Status: PROVISIONAL

Source sequence(s)

AF061274

Consensus CDS

CCDS29931.1

UniProtKB/Swiss-Prot

O70478, Q5BKQ4, Q6NV82

Related

ENSMUSP00000045465.6, ENSMUST00000048644.6

Conserved Domains (2) summary

cd01759
Location:356 → 467

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:18 → 353

Lipase