Flrt1 fibronectin leucine rich transmembrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flrt1provided by MGI
Official Full Name: fibronectin leucine rich transmembrane protein 1provided by MGI
Primary source: MGI:MGI:3026647
See related: Ensembl:ENSMUSG00000047787 AllianceGenome:MGI:3026647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D630040I23Rik
Summary: Enables fibroblast growth factor receptor binding activity. Involved in dendrite development; fibroblast growth factor receptor signaling pathway; and neuron projection extension. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including neuron projection terminus; neuronal cell body membrane; and perinuclear region of cytoplasm. Colocalizes with focal adhesion. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; neural ectoderm; and sensory organ. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 10.2), cortex adult (RPKM 2.7) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.2 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7064829..7143548, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7087464..7166183, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
FLRT1 is expressed at brain compartmental boundaries in embryo
Title: Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat transmembrane protein FLRT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201411.2 → NP_958813.1 leucine-rich repeat transmembrane protein FLRT1 precursor

See identical proteins and their annotated locations for NP_958813.1

Status: VALIDATED

Source sequence(s)

AC109619, AK031503, BE947674

Consensus CDS

CCDS29519.1

UniProtKB/Swiss-Prot

A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9

Related

ENSMUSP00000109010.3, ENSMUST00000113383.4

Conserved Domains (4) summary

PRK15370
Location:58 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:300 → 406

PCC; polycystin cation channel protein

smart00060
Location:441 → 505

FN3; Fibronectin type 3 domain

sd00033
Location:108 → 128

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7064829..7143548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527170.4 → XP_006527233.1 leucine-rich repeat transmembrane protein FLRT1 isoform X1

See identical proteins and their annotated locations for XP_006527233.1

UniProtKB/Swiss-Prot

A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9

Conserved Domains (4) summary

PRK15370
Location:58 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:300 → 406

PCC; polycystin cation channel protein

smart00060
Location:441 → 505

FN3; Fibronectin type 3 domain

sd00033
Location:108 → 128

LRR_RI; leucine-rich repeat [structural motif]
XM_006527169.3 → XP_006527232.1 leucine-rich repeat transmembrane protein FLRT1 isoform X1

See identical proteins and their annotated locations for XP_006527232.1

UniProtKB/Swiss-Prot

A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9

Conserved Domains (4) summary

PRK15370
Location:58 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:300 → 406

PCC; polycystin cation channel protein

smart00060
Location:441 → 505

FN3; Fibronectin type 3 domain

sd00033
Location:108 → 128

LRR_RI; leucine-rich repeat [structural motif]
XM_006527171.5 → XP_006527234.1 leucine-rich repeat transmembrane protein FLRT1 isoform X1

See identical proteins and their annotated locations for XP_006527234.1

UniProtKB/Swiss-Prot

A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9

Conserved Domains (4) summary

PRK15370
Location:58 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:300 → 406

PCC; polycystin cation channel protein

smart00060
Location:441 → 505

FN3; Fibronectin type 3 domain

sd00033
Location:108 → 128

LRR_RI; leucine-rich repeat [structural motif]