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    Fsd1l fibronectin type III and SPRY domain containing 1-like [ Mus musculus (house mouse) ]

    Gene ID: 319636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fsd1lprovided by MGI
    Official Full Name
    fibronectin type III and SPRY domain containing 1-likeprovided by MGI
    Primary source
    MGI:MGI:2442443
    See related
    Ensembl:ENSMUSG00000054752 AllianceGenome:MGI:2442443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc10; Fsd1nl; Csdufd1; A230072O16Rik
    Summary
    Orthologous to human FSD1L (fibronectin type III and SPRY domain containing 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 4.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fsd1l in Genome Data Viewer
    Location:
    4 B2; 4 28.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53631383..53707009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53631383..53707009)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 44, member 1 Neighboring gene RIKEN cDNA 1700060J05 gene Neighboring gene predicted gene, 54226 Neighboring gene single stranded DNA binding protein 4 pseudogene Neighboring gene fukutin Neighboring gene T cell acute lymphocytic leukemia 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    FSD1-like protein
    Names
    FSD1 N-terminal-like protein
    coiled-coil domain-containing protein 10
    cystatin and DUF19 domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195284.1 → NP_001182213.1  FSD1-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This variant lacks full-length support in mouse; it is predicted based on partial mouse and full-length human transcript alignments from GeneID:83856.
      Source sequence(s)
      AL807745, BB626514, BB662298, CJ115006, CJ261972
      Consensus CDS
      CCDS57276.1
      UniProtKB/TrEMBL
      E0CXZ1
      Related
      ENSMUSP00000114931.2, ENSMUST00000132151.8
      Conserved Domains (3) summary
      cd00063
      Location:165 → 265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270 → 473
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
      cl23765
      Location:4 → 130
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001355377.1 → NP_001342306.1  FSD1-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
      Source sequence(s)
      AK052914, AL807745, BB626514, CJ115006, CJ261972
      UniProtKB/TrEMBL
      E0CXZ1
      Related
      ENSMUSP00000124613.3, ENSMUST00000163067.9
      Conserved Domains (3) summary
      cd00063
      Location:165 → 265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270 → 472
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
      cl25407
      Location:4 → 130
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    3. NM_001369182.1 → NP_001356111.1  FSD1-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL807745
      Conserved Domains (2) summary
      cd00063
      Location:52 → 140
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:145 → 348
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

    4. NM_176966.4 → NP_795940.1  FSD1-like protein isoform 2

      See identical proteins and their annotated locations for NP_795940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons and differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is significantly shorter than isoform 1.
      Source sequence(s)
      AL807745, BC130265
      UniProtKB/TrEMBL
      A1L3T0
      Related
      ENSMUST00000107643.8
      Conserved Domains (1) summary
      cl23765
      Location:4 → 113
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      53631383..53707009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537980.4 → XP_006538043.1  FSD1-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q3USW7, Q8BYN5
      Related
      ENSMUSP00000124002.3, ENSMUST00000159415.9
      Conserved Domains (3) summary
      smart00502
      Location:4 → 130
      BBC; B-Box C-terminal domain
      cd00063
      Location:165 → 265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270 → 484
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

    2. XM_036164182.1 → XP_036020075.1  FSD1-like protein isoform X3

      Conserved Domains (2) summary
      cd00063
      Location:52 → 140
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:145 → 359
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

    3. XM_036164183.1 → XP_036020076.1  FSD1-like protein isoform X4

      Conserved Domains (2) summary
      cd00063
      Location:2 → 78
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:83 → 297
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

    4. XM_017320255.3 → XP_017175744.1  FSD1-like protein isoform X2

      Conserved Domains (2) summary
      cd00063
      Location:94 → 182
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:187 → 401
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

    RNA

    1. XR_004941920.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYN5.2 GenPept UniProtKB/Swiss-Prot:Q8BYN5

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