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    Mob3b MOB kinase activator 3B [ Mus musculus (house mouse) ]

    Gene ID: 214944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mob3bprovided by MGI
    Official Full Name
    MOB kinase activator 3Bprovided by MGI
    Primary source
    MGI:MGI:2664539
    See related
    Ensembl:ENSMUSG00000073910 AllianceGenome:MGI:2664539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mobkl2b; 8430436F23Rik; A430018A01Rik
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in regulation of hippo signaling and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; lower jaw incisor; lower jaw molar; upper jaw incisor; and upper jaw molar. Orthologous to human MOB3B (MOB kinase activator 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 2.5), liver adult (RPKM 2.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mob3b in Genome Data Viewer
    Location:
    4 A5; 4 16.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34949074..35157490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34949074..35157524, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:34905638-34905939 Neighboring gene predicted gene 12362 Neighboring gene STARR-seq mESC enhancer starr_09933 Neighboring gene STARR-seq mESC enhancer starr_09934 Neighboring gene predicted gene, 33620 Neighboring gene predicted gene, 52727 Neighboring gene STARR-positive B cell enhancer ABC_E9236 Neighboring gene STARR-positive B cell enhancer mm9_chr4:35078889-35079190 Neighboring gene STARR-seq mESC enhancer starr_09939 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:35103331-35103583 Neighboring gene interferon kappa Neighboring gene C9orf72, member of C9orf72-SMCR8 complex Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:35173352-35173535 Neighboring gene uncharacterized LOC118568669

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice. Vassileva G, et al. J Immunol, 2003 Jun 1. PMID 12759458
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3B
    Names
    MOB1 (Mps One Binder) kinase activator-like 2B
    mob1 homolog 2b
    mps one binder kinase activator-like 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178061.5 → NP_835162.1  MOB kinase activator 3B

      See identical proteins and their annotated locations for NP_835162.1

      Status: VALIDATED

      Source sequence(s)
      AK039841, AK087285, AL929565
      Consensus CDS
      CCDS18036.1
      UniProtKB/Swiss-Prot
      Q3U2L2, Q8BU65, Q8VE04
      UniProtKB/TrEMBL
      Q3TC05
      Related
      ENSMUSP00000100040.4, ENSMUST00000102975.10
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34949074..35157490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253394.2 → XP_030109254.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q3U2L2, Q8BU65, Q8VE04
      UniProtKB/TrEMBL
      Q3TC05
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    2. XM_006537753.4 → XP_006537816.1  MOB kinase activator 3B isoform X1

      See identical proteins and their annotated locations for XP_006537816.1

      UniProtKB/Swiss-Prot
      Q3U2L2, Q8BU65, Q8VE04
      UniProtKB/TrEMBL
      Q3TC05
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    3. XM_036163953.1 → XP_036019846.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q3U2L2, Q8BU65, Q8VE04
      UniProtKB/TrEMBL
      Q3TC05
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    4. XM_006537752.5 → XP_006537815.1  MOB kinase activator 3B isoform X1

      See identical proteins and their annotated locations for XP_006537815.1

      UniProtKB/Swiss-Prot
      Q3U2L2, Q8BU65, Q8VE04
      UniProtKB/TrEMBL
      Q3TC05
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    5. XM_006537755.5 → XP_006537818.1  MOB kinase activator 3B isoform X2

      UniProtKB/TrEMBL
      Q3TC05
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE04.1 GenPept UniProtKB/Swiss-Prot:Q8VE04

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