Oas1a 2'-5' oligoadenylate synthetase 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oas1aprovided by MGI
Official Full Name: 2'-5' oligoadenylate synthetase 1Aprovided by MGI
Primary source: MGI:MGI:2180860
See related: Ensembl:ENSMUSG00000052776 AllianceGenome:MGI:2180860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L3
Summary: Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in purine nucleotide biosynthetic process. Acts upstream of or within negative regulation of viral process. Predicted to be located in mitochondrion; nucleus; and ribosome. Predicted to be active in cytosol; membrane; and nucleoplasm. Predicted to colocalize with cytoplasm. Is expressed in appendicular skeleton; axial skeleton; lower jaw; and testis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 22.5), colon adult (RPKM 20.5) and 18 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 F; 5 60.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121034319..121045588, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120896256..120907544, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling.
Title: Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Mouse hepatitis virus Ns2 cleaves 2',5'-oligoadenylate, the product of 2',5'-oligoadenylate synthetase, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RNA degradation.
Title: Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2
Title: Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.
In the absence of a functional OAS1a pathway, herpes simplex virus type 1 antigen expression is more widespread, and the ability of IFN-beta transgene treatment to reduce infectious HSV-1 in eyes and trigeminal ganglia is lost.
Title: Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI449562 (e-PCR)
- UniSTS:185638

X58077 (e-PCR)
- UniSTS:125806

Oas1g (e-PCR), detects polymorphism
- UniSTS:259455

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of viral process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	TAS Traceable Author Statement more info	PubMed
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: 2'-5'-oligoadenylate synthase 1A

Names: (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1A; 2-5A synthase 1A; 2-5A synthetase 1A; p42 OAS

NP_001411632.1

EC 2.7.7.84

NP_001411633.1

EC 2.7.7.84

NP_001411634.1

EC 2.7.7.84

NP_001411635.1

EC 2.7.7.84

NP_001411636.1

EC 2.7.7.84

NP_001411637.1

EC 2.7.7.84

NP_001411638.1

EC 2.7.7.84

NP_001411639.1

EC 2.7.7.84

NP_001411640.1

EC 2.7.7.84

NP_660212.2

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424703.1 → NP_001411632.1 2'-5'-oligoadenylate synthase 1A isoform 2

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424704.1 → NP_001411633.1 2'-5'-oligoadenylate synthase 1A isoform 3

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424705.1 → NP_001411634.1 2'-5'-oligoadenylate synthase 1A isoform 4

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424706.1 → NP_001411635.1 2'-5'-oligoadenylate synthase 1A isoform 5

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424707.1 → NP_001411636.1 2'-5'-oligoadenylate synthase 1A isoform 6

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424708.1 → NP_001411637.1 2'-5'-oligoadenylate synthase 1A isoform 7

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424709.1 → NP_001411638.1 2'-5'-oligoadenylate synthase 1A isoform 8

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424710.1 → NP_001411639.1 2'-5'-oligoadenylate synthase 1A isoform 9

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_001424711.1 → NP_001411640.1 2'-5'-oligoadenylate synthase 1A isoform 10

Status: VALIDATED

Source sequence(s)

AC015535

UniProtKB/TrEMBL

Q8VEH7
NM_145211.2 → NP_660212.2 2'-5'-oligoadenylate synthase 1A isoform 1

See identical proteins and their annotated locations for NP_660212.2

Status: VALIDATED

Source sequence(s)

AC015535, AK149613, BU699042

Consensus CDS

CCDS19630.1

UniProtKB/Swiss-Prot

F2Z419, P11928, Q3UEC1, Q64440, Q91VI0

UniProtKB/TrEMBL

Q8VEH7

Related

ENSMUSP00000079198.8, ENSMUST00000080322.8

Conserved Domains (2) summary

cd05400
Location:29 → 212

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:164 → 348

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus