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    Zan zonadhesin [ Mus musculus (house mouse) ]

    Gene ID: 22635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zanprovided by MGI
    Official Full Name
    zonadhesinprovided by MGI
    Primary source
    MGI:MGI:106656
    See related
    Ensembl:ENSMUSG00000079173 AllianceGenome:MGI:106656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zan-test
    Summary
    Predicted to enable extracellular matrix binding activity. Acts upstream of or within regulation of binding activity of sperm to zona pellucida. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human ZAN (zonadhesin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 10.7), testis adult (RPKM 4.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zan in Genome Data Viewer
    Location:
    5 G2; 5 76.4 cM
    Exon count:
    91
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137376899..137475326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137378637..137477064, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52791 Neighboring gene Eph receptor B4 Neighboring gene STARR-seq mESC enhancer starr_14643 Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725 Neighboring gene predicted gene, 36056 Neighboring gene erythropoietin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. Gao Z, et al. J Biol Chem, 1998 Feb 6. PMID 9452463
    2. Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Wheeler K, et al. Proc Natl Acad Sci U S A, 2011 May 3. PMID 21502500, Free PMC Article
    3. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. Tardif S, et al. J Biol Chem, 2010 Aug 6. PMID 20529856, Free PMC Article
    4. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. Hardy DM, et al. J Biol Chem, 1995 Nov 3. PMID 7592795
    5. Genetic analysis of inferior nurturing ability in RR mice. Suto J, et al. Reproduction, 2002 Jan. PMID 11869186

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida
      Title: Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zonadhesin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011741.2 → NP_035871.2  zonadhesin precursor

      Status: VALIDATED

      Source sequence(s)
      AC148018, AC150682
      Consensus CDS
      CCDS51672.1
      UniProtKB/TrEMBL
      E9PWQ7, Q99ND0
      Related
      ENSMUSP00000114068.2, ENSMUST00000117564.8
      Conserved Domains (9) summary
      cd06263
      Location:379 → 540
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 542
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1599 → 1652
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2310 → 2380
      C8; C8 domain
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      pfam15950
      Location:729 → 899
      DUF4758; Domain of unknown function (DUF4758)
      cl17735
      Location:5249 → 5302
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137376899..137475326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165001.1 → XP_036020894.1  zonadhesin isoform X2

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      smart00832
      Location:1895 → 1966
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3505 → 3559
      TILa; TILa domain
      cl17735
      Location:2025 → 2080
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1699 → 1849
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5178 → 5231
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2306 → 2364
      C8; C8 domain
      cd19941
      Location:1583 → 1636
      TIL; trypsin inhibitor-like cysteine rich domain

    2. XM_036165003.1 → XP_036020896.1  zonadhesin isoform X4

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      smart00832
      Location:1871 → 1942
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3481 → 3535
      TILa; TILa domain
      cl17735
      Location:2001 → 2056
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1675 → 1825
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5154 → 5207
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2282 → 2340
      C8; C8 domain
      cd19941
      Location:1559 → 1612
      TIL; trypsin inhibitor-like cysteine rich domain

    3. XM_036165000.1 → XP_036020893.1  zonadhesin isoform X1

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      smart00832
      Location:1906 → 1977
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3516 → 3570
      TILa; TILa domain
      cl17735
      Location:2036 → 2091
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1710 → 1860
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5189 → 5242
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2317 → 2375
      C8; C8 domain
      cd19941
      Location:1594 → 1647
      TIL; trypsin inhibitor-like cysteine rich domain

    4. XM_036165005.1 → XP_036020898.1  zonadhesin isoform X6

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3281 → 3335
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:4954 → 5007
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain
      cd19941
      Location:1599 → 1652
      TIL; trypsin inhibitor-like cysteine rich domain

    5. XM_036165004.1 → XP_036020897.1  zonadhesin isoform X5

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3401 → 3455
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5074 → 5127
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain
      cd19941
      Location:1599 → 1652
      TIL; trypsin inhibitor-like cysteine rich domain

    6. XM_036165002.1 → XP_036020895.1  zonadhesin isoform X3

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (10) summary
      cd06263
      Location:217 → 345
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00832
      Location:1885 → 1956
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:520 → 914
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3495 → 3549
      TILa; TILa domain
      cl17735
      Location:2015 → 2070
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1689 → 1839
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:353 → 515
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5168 → 5221
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2296 → 2354
      C8; C8 domain
      cd19941
      Location:1573 → 1626
      TIL; trypsin inhibitor-like cysteine rich domain

    7. XM_017320810.1 → XP_017176299.1  zonadhesin isoform X7

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      PHA03255
      Location:777 → 932
      PHA03255; BDLF3; Provisional
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1599 → 1652
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain
      pfam17823
      Location:546 → 838
      DUF5585; Family of unknown function (DUF5585)

    8. XM_017320811.1 → XP_017176300.1  zonadhesin isoform X8

      UniProtKB/TrEMBL
      Q99ND0
      Conserved Domains (9) summary
      PHA03255
      Location:777 → 932
      PHA03255; BDLF3; Provisional
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1599 → 1652
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain
      pfam17823
      Location:546 → 838
      DUF5585; Family of unknown function (DUF5585)

    9. XM_036165006.1 → XP_036020899.1  zonadhesin isoform X9

      Conserved Domains (9) summary
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1985 → 2039
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain
      cd19941
      Location:1599 → 1652
      TIL; trypsin inhibitor-like cysteine rich domain

    10. XM_017320813.2 → XP_017176302.1  zonadhesin isoform X10

      Conserved Domains (9) summary
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      TIGR03835
      Location:817 → 1153
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1599 → 1652
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain

    11. XM_017320814.1 → XP_017176303.1  zonadhesin isoform X11

      Conserved Domains (9) summary
      smart00832
      Location:1911 → 1982
      C8; This domain contains 8 conserved cysteine residues
      TIGR03835
      Location:817 → 1153
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam05109
      Location:546 → 940
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:3521 → 3575
      TILa; TILa domain
      cl17735
      Location:2041 → 2096
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1715 → 1865
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:379 → 541
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:1599 → 1652
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2322 → 2380
      C8; C8 domain

    RNA

    1. XR_003955622.1 RNA Sequence

    2. XR_003955623.1 RNA Sequence

    3. XR_001784667.1 RNA Sequence

    4. XR_001784665.1 RNA Sequence

    5. XR_001784666.1 RNA Sequence

    6. XR_004942494.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88799.1 GenPept UniProtKB/Swiss-Prot:O88799

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