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    Mill1 MHC I like leukocyte 1 [ Mus musculus (house mouse) ]

    Gene ID: 266815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mill1provided by MGI
    Official Full Name
    MHC I like leukocyte 1provided by MGI
    Primary source
    MGI:MGI:2179988
    See related
    Ensembl:ENSMUSG00000054005 AllianceGenome:MGI:2179988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5530400I18Rik
    Summary
    Predicted to enable natural killer cell lectin-like receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; defense response to other organism; and regulation of leukocyte mediated cytotoxicity. Located in external side of plasma membrane. Orthologous to human MICA (MHC class I polypeptide-related sequence A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Mill1 in Genome Data Viewer
    Location:
    7 A2; 7 9.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (17979150..18000017)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18245225..18266092)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18163 Neighboring gene IGF-like family member 3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18167 Neighboring gene pregnancy specific beta-1-glycoprotein 18 Neighboring gene STARR-seq mESC enhancer starr_18168 Neighboring gene myotubularin related protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing. Rabinovich BA, et al. Immunol Cell Biol, 2008 Aug-Sep. PMID 18560379
    2. Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. Ritter C, et al. Sci Rep, 2016 Feb 23. PMID 26902929, Free PMC Article
    3. MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression. Kajikawa M, et al. J Immunol, 2006 Sep 1. PMID 16920948
    4. Recognition of the ligand-type specificity of classical and non-classical MHC I proteins. Martínez-Naves E, et al. FEBS Lett, 2011 Nov 4. PMID 22001201
    5. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Kasahara M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370446, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reversal of epigenetic silencing of MICA and MICB improves immune recognition and killing of Merkel cell carcinoma cells.
      Title: Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
    2. Our results suggest a role for the Mill proteins in cellular metabolism, with possible therapeutic significance.
      Title: A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.
    3. Mill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains.
      Title: A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.
    4. two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m)
      Title: MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129328, MGC129329

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-delta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MHC class I-like protein MILL1
    Names
    MHC class I-like located near the leukocyte receptor complex 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153749.4 → NP_715630.3  MHC class I-like protein MILL1 precursor

      See identical proteins and their annotated locations for NP_715630.3

      Status: VALIDATED

      Source sequence(s)
      AC151983, AK029010
      Consensus CDS
      CCDS20868.1
      UniProtKB/Swiss-Prot
      Q8HWA4, Q8HWA5, Q8HWE7
      Related
      ENSMUSP00000069083.5, ENSMUST00000066780.5
      Conserved Domains (3) summary
      cd00096
      Location:242 → 248
      Ig; Ig strand A [structural motif]
      cl08246
      Location:60 → 229
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:242 → 323
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      17979150..18000017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540014.2 → XP_006540077.1  MHC class I-like protein MILL1 isoform X2

      Conserved Domains (1) summary
      cl08246
      Location:61 → 130
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. XM_006540013.2 → XP_006540076.1  MHC class I-like protein MILL1 isoform X1

      See identical proteins and their annotated locations for XP_006540076.1

      Conserved Domains (2) summary
      cl08246
      Location:2 → 161
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:174 → 255
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8HWE7.1 GenPept UniProtKB/Swiss-Prot:Q8HWE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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