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    Ccdc126 coiled-coil domain containing 126 [ Mus musculus (house mouse) ]

    Gene ID: 57895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc126provided by MGI
    Official Full Name
    coiled-coil domain containing 126provided by MGI
    Primary source
    MGI:MGI:1889376
    See related
    Ensembl:ENSMUSG00000050786 AllianceGenome:MGI:1889376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330407D12Rik
    Summary
    Predicted to be located in extracellular region. Is expressed in several structures, including intestine; liver; metanephros; retina nuclear layer; and skeletal muscle. Orthologous to human CCDC126 (coiled-coil domain containing 126). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.2), bladder adult (RPKM 3.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc126 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49296204..49318521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49319269..49341587)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:49214021-49214322 Neighboring gene transformer 2 alpha Neighboring gene STARR-seq mESC enhancer starr_15823 Neighboring gene STARR-seq mESC enhancer starr_15824 Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene family with sequence similarity 221, member A Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene serine threonine kinase 31 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143769

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 126

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311112.1 → NP_001298041.1  coiled-coil domain-containing protein 126 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001298041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the coding region, leading to a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC095987, BX513032, BY126756, CK626366
      Consensus CDS
      CCDS80531.1
      UniProtKB/Swiss-Prot
      Q8BIS8
      Related
      ENSMUSP00000110135.2, ENSMUST00000114491.2
      Conserved Domains (1) summary
      pfam15027
      Location:4 → 79
      DUF4525; Domain of unknown function (DUF4525)

    2. NM_175098.6 → NP_780307.1  coiled-coil domain-containing protein 126 isoform 1 precursor

      See identical proteins and their annotated locations for NP_780307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK018135, BC095987, BX513032, BY126756
      Consensus CDS
      CCDS20125.1
      UniProtKB/Swiss-Prot
      Q3TXH2, Q501L9, Q8BIS8
      Related
      ENSMUSP00000058077.8, ENSMUST00000055559.8
      Conserved Domains (1) summary
      pfam15027
      Location:4 → 137
      DUF4525; Domain of unknown function (DUF4525)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49296204..49318521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241420.4 → XP_011239722.1  coiled-coil domain-containing protein 126 isoform X1

      See identical proteins and their annotated locations for XP_011239722.1

      UniProtKB/Swiss-Prot
      Q3TXH2, Q501L9, Q8BIS8
      Conserved Domains (1) summary
      pfam15027
      Location:4 → 137
      DUF4525; Domain of unknown function (DUF4525)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIS8.1 GenPept UniProtKB/Swiss-Prot:Q8BIS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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