Slc44a2 solute carrier family 44, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc44a2provided by MGI
Official Full Name: solute carrier family 44, member 2provided by MGI
Primary source: MGI:MGI:1915932
See related: Ensembl:ENSMUSG00000057193 AllianceGenome:MGI:1915932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTL2; 1110028E10Rik
Summary: Predicted to enable choline transmembrane transporter activity and ethanolamine transmembrane transporter activity. Predicted to be involved in choline transport; ethanolamine transport; and transmembrane transport. Predicted to be located in mitochondrial outer membrane and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including inner ear. Orthologous to human SLC44A2 (solute carrier family 44 member 2 (CTL2 blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 112.2), lung adult (RPKM 80.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.77 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21232015..21266324)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21320719..21355028)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
Title: Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis.
Title: SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis.
Plasma Protein Signatures of a Murine Venous Thrombosis Model and Slc44a2 Knockout Mice Using Quantitative-Targeted Proteomics.
Title: Plasma Protein Signatures of a Murine Venous Thrombosis Model and Slc44a2 Knockout Mice Using Quantitative-Targeted Proteomics.
The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.
Title: The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.
Mice lacking SLC44A2 are normal for several hemostasis parameters. Lower levels of circulating plasma VWF are measured in SLC44A2 deficient mice.
Title: Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2.
The findings show that, for binding to CTL2, Type 2 HNA-3a antibodies require nonpolymorphic amino acid residues in the third, and possibly the second, EC loops of CTL2
Title: Transfusion-related acute lung injury-associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2.
Report age related changes between the two isoforms of CTL2/SLC44A2 in the inner ear.
Title: Age-related changes in expression of CTL2/SLC44A2 and its isoforms in the mouse inner ear.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

dxmgh7 (e-PCR)
- UniSTS:120588

NoName (e-PCR)
- UniSTS:236064

Slc44a2 (e-PCR), detects polymorphism
- UniSTS:547112

35.MMHAP10FD5.seq (e-PCR)
- UniSTS:124126

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanolamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in ethanolamine transport	ISO Inferred from Sequence Orthology more info
involved_in ethanolamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: choline transporter-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199186.1 → NP_001186115.1 choline transporter-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_001186115.1

Status: VALIDATED

Source sequence(s)

AK041533, BU756489, BY339157

Consensus CDS

CCDS90511.1

UniProtKB/Swiss-Prot

Q8BY89

Related

ENSMUSP00000150147.2, ENSMUST00000217461.2

Conserved Domains (2) summary

pfam04515
Location:317 → 673

Choline_transpo; Plasma-membrane choline transporter

cl01738
Location:226 → 322

DUF898; Bacterial protein of unknown function (DUF898)
NM_001359227.1 → NP_001346156.1 choline transporter-like protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC122525

Conserved Domains (2) summary

pfam04515
Location:318 → 673

Choline_transpo; Plasma-membrane choline transporter

cl26602
Location:245 → 275

SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
NM_152808.3 → NP_690021.1 choline transporter-like protein 2 isoform 2

See identical proteins and their annotated locations for NP_690021.1

Status: VALIDATED

Source sequence(s)

AK048648, AK166695, BU756489

Consensus CDS

CCDS22903.1

UniProtKB/Swiss-Prot

Q8BY89, Q8K2F1

Related

ENSMUSP00000034697.8, ENSMUST00000034697.8

Conserved Domains (2) summary

pfam04515
Location:319 → 675

Choline_transpo; Plasma-membrane choline transporter

cl01738
Location:228 → 324

DUF898; Bacterial protein of unknown function (DUF898)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

21232015..21266324

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242593.3 → XP_011240895.1 choline transporter-like protein 2 isoform X1

Conserved Domains (2) summary

cl38913
Location:258 → 298

ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters

pfam04515
Location:341 → 697

Choline_transpo; Plasma-membrane choline transporter
XM_030244550.1 → XP_030100410.1 choline transporter-like protein 2 isoform X2

Conserved Domains (2) summary

TIGR03375
Location:268 → 298

type_I_sec_LssB; type I secretion system ATPase, LssB family

pfam04515
Location:341 → 697

Choline_transpo; Plasma-membrane choline transporter
XM_036155232.1 → XP_036011125.1 choline transporter-like protein 2 isoform X1

Conserved Domains (2) summary

cl38913
Location:258 → 298

ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters

pfam04515
Location:341 → 697

Choline_transpo; Plasma-membrane choline transporter
XM_006510576.3 → XP_006510639.1 choline transporter-like protein 2 isoform X3

Conserved Domains (2) summary

TIGR03375
Location:247 → 277

type_I_sec_LssB; type I secretion system ATPase, LssB family

pfam04515
Location:320 → 676

Choline_transpo; Plasma-membrane choline transporter