U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mpzl3 myelin protein zero-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 319742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpzl3provided by MGI
    Official Full Name
    myelin protein zero-like 3provided by MGI
    Primary source
    MGI:MGI:2442647
    See related
    Ensembl:ENSMUSG00000070305 AllianceGenome:MGI:2442647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rc; ruf; 5430427F17Rik; A530065I17Rik
    Summary
    Acts upstream of or within extracellular matrix organization and hair cycle. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MPZL3 (myelin protein zero like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 4.2), small intestine adult (RPKM 3.4) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mpzl3 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44966479..44988735)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45055181..45077437)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CD3 antigen, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_23989 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44849180-44849480 Neighboring gene myelin protein zero-like 2 Neighboring gene STARR-seq mESC enhancer starr_23990 Neighboring gene junction adhesion molecule like Neighboring gene predicted gene 10684 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44929112-44929313 Neighboring gene sodium channel, voltage-gated, type II, beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    rough coat
    GeneReviews: Not available
    rough fur
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Spontaneous (3) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    myelin protein zero-like protein 3
    Names
    Ig-like domain-containing protein UNQ2966

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093749.3NP_001087218.1  myelin protein zero-like protein 3 precursor

      See identical proteins and their annotated locations for NP_001087218.1

      Status: VALIDATED

      Source sequence(s)
      AC122305, EF102773
      Consensus CDS
      CCDS52781.1
      UniProtKB/Swiss-Prot
      A5H7F1, Q3V3F6
      Related
      ENSMUSP00000110312.3, ENSMUST00000114664.8
      Conserved Domains (2) summary
      smart00410
      Location:40148
      IG_like; Immunoglobulin like
      cl11960
      Location:34137
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44966479..44988735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176993.3: Suppressed sequence

      Description
      NM_176993.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.