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    Tmem185a transmembrane protein 185A [ Mus musculus (house mouse) ]

    Gene ID: 236848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem185aprovided by MGI
    Official Full Name
    transmembrane protein 185Aprovided by MGI
    Primary source
    MGI:MGI:2448555
    See related
    Ensembl:ENSMUSG00000073139 AllianceGenome:MGI:2448555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ee3
    Summary
    Located in dendrite. Orthologous to human TMEM185A (transmembrane protein 185A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 11.8), bladder adult (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem185a in Genome Data Viewer
    Location:
    X A7.2; X 36.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (69503359..69520796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (70459753..70477180, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene melanoma antigen, family A, 4 pseudogene Neighboring gene predicted gene 14721 Neighboring gene STARR-seq mESC enhancer starr_47317 Neighboring gene predicted gene 14727 Neighboring gene melanoma antigen, family A, 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. Maurer MH, et al. J Neurochem, 2004 Nov. PMID 15525354
    2. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs.
      Title: Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 185A
    Names
    erythropoietin-induced EST 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033328.3 → NP_001028500.1  transmembrane protein 185A isoform 2

      See identical proteins and their annotated locations for NP_001028500.1

      Status: VALIDATED

      Source sequence(s)
      AK158294, AL672026
      Consensus CDS
      CCDS30176.1
      UniProtKB/TrEMBL
      Q3TYW3
      Related
      ENSMUSP00000099043.4, ENSMUST00000101506.10
      Conserved Domains (1) summary
      pfam10269
      Location:31 → 225
      Tmemb_185A; Transmembrane Fragile-X-F protein

    2. NM_001357750.1 → NP_001344679.1  transmembrane protein 185A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672026, BC145368
      Consensus CDS
      CCDS90721.1
      UniProtKB/Swiss-Prot
      A2AF53
      Related
      ENSMUSP00000110277.3, ENSMUST00000114630.3
      Conserved Domains (1) summary
      pfam10269
      Location:31 → 253
      Tmemb_185A; Transmembrane Fragile-X-F protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      69503359..69520796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318471.3 → XP_017173960.1  transmembrane protein 185A isoform X1

      Conserved Domains (1) summary
      pfam10269
      Location:4 → 170
      Tmemb_185A; Transmembrane Fragile-X-F protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AF53.1 GenPept UniProtKB/Swiss-Prot:A2AF53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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