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    Kcnip2 Kv channel-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 80906, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnip2provided by MGI
    Official Full Name
    Kv channel-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2135916
    See related
    Ensembl:ENSMUSG00000025221 AllianceGenome:MGI:2135916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KChIP2
    Summary
    This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
    Expression
    Biased expression in heart adult (RPKM 60.6), cortex adult (RPKM 30.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kcnip2 in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45780785..45804948, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45792346..45816422, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11033 Neighboring gene nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene armadillo-like helical domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene STARR-seq mESC enhancer starr_46288 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46291 Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E4287 Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to A-type (transient outward) potassium channel activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables identical protein binding  
    enables potassium channel activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity PubMed 
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables protein-containing complex binding  
    enables transmembrane transporter binding  
    Component Evidence Code Pubs
    part_of Kv4.2-KChIP2 channel complex  
    located_in cytoplasm  
    located_in dendrite  
    located_in plasma membrane PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    A-type potassium channel modulatory protein KCNIP2; Kv channel-interacting protein 2
    Names
    A-type potassium channel modulatory protein 2
    potassium channel-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276358.1NP_001263287.1  A-type potassium channel modulatory protein KCNIP2 isoform d

      See identical proteins and their annotated locations for NP_001263287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) uses an alternate 5' exon structure, lacks an in-frame segment in the coding region, and initiates translation at an alternate start codon, compared to variant a. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AY647241, BC056434
      Consensus CDS
      CCDS70955.1
      UniProtKB/TrEMBL
      Q3YAA4
      Related
      ENSMUSP00000084215.5, ENSMUST00000086993.11
      Conserved Domains (1) summary
      COG5126
      Location:48214
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. NM_001424873.1NP_001411802.1  A-type potassium channel modulatory protein KCNIP2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC149086
      UniProtKB/TrEMBL
      A0A5F8MPB0
      Related
      ENSMUSP00000158890.2, ENSMUST00000239049.2
    3. NM_030716.3NP_109641.2  A-type potassium channel modulatory protein KCNIP2 isoform b

      See identical proteins and their annotated locations for NP_109641.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an internal exon in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      BC056434, CX122626, DQ148497
      Consensus CDS
      CCDS50453.1
      UniProtKB/TrEMBL
      E9QNK8, Q3YAB2
      Related
      ENSMUSP00000078400.4, ENSMUST00000079431.10
      Conserved Domains (1) summary
      COG5126
      Location:75241
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    4. NM_145703.2NP_663749.1  A-type potassium channel modulatory protein KCNIP2 isoform a

      See identical proteins and their annotated locations for NP_663749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also known as KCHIP2L).
      Source sequence(s)
      BC056434, CX122626, DQ148496
      Consensus CDS
      CCDS38004.1
      UniProtKB/Swiss-Prot
      Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
      UniProtKB/TrEMBL
      Q3YAB3
      Related
      ENSMUSP00000125142.3, ENSMUST00000162528.9
      Conserved Domains (1) summary
      COG5126
      Location:93259
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    5. NM_145704.2NP_663750.1  A-type potassium channel modulatory protein KCNIP2 isoform c

      See identical proteins and their annotated locations for NP_663750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks two consecutive internal exons in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (c, also known as KCHIP2S) is shorter, compared to isoform a.
      Source sequence(s)
      BC056434, BC138496, CX122626
      Consensus CDS
      CCDS29868.1
      UniProtKB/TrEMBL
      E0CY54, E9QNK8, Q3YAB1
      Related
      ENSMUSP00000124482.3, ENSMUST00000161886.9
      Conserved Domains (1) summary
      COG5126
      Location:43209
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45780785..45804948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527470.5XP_006527533.1  Kv channel-interacting protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
      Conserved Domains (1) summary
      COG5126
      Location:109275
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. XM_017318315.3XP_017173804.1  Kv channel-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
      UniProtKB/TrEMBL
      Q3YAB3
      Conserved Domains (1) summary
      COG5126
      Location:93259
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
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