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    Gucy2c guanylate cyclase 2c [ Mus musculus (house mouse) ]

    Gene ID: 14917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gucy2cprovided by MGI
    Official Full Name
    guanylate cyclase 2cprovided by MGI
    Primary source
    MGI:MGI:106903
    See related
    Ensembl:ENSMUSG00000042638 AllianceGenome:MGI:106903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcc; GC-C
    Summary
    Enables guanylate cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system; liver; and spinal cord. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 40.4), colon adult (RPKM 29.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gucy2c in Genome Data Viewer
    Location:
    6 G1; 6 66.67 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136674282..136758740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136697284..136781742, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 1 Neighboring gene predicted gene, 40409 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene protein S100-A10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136692382-136692565 Neighboring gene predicted gene, 40411 Neighboring gene H4 histone 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine. Swenson ES, et al. Biochem Biophys Res Commun, 1996 Aug 23. PMID 8780725
    2. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Li P, et al. Am J Pathol, 2007 Dec. PMID 17974601, Free PMC Article
    3. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. Snook AE, et al. J Natl Cancer Inst, 2008 Jul 2. PMID 18577748, Free PMC Article
    4. Sex modulates intestinal transformation by the tumor-suppressor GCC. Li P, et al. Clin Transl Sci, 2008 Sep. PMID 20443837, Free PMC Article
    5. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Gong R, et al. Science, 2011 Sep 16. PMID 21835979

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intestinal neuropod cell GUCY2C regulates visceral pain.
      Title: Intestinal neuropod cell GUCY2C regulates visceral pain.
    2. Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
      Title: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
    3. The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
      Title: The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
    4. Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
      Title: Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
    5. Study reveals two discrete neuronal circuits expressing GUCY2C originating in the ventral premammillary nucleus in the hypothalamus and in the ventral tegmental area and substantia nigra in midbrain, which separately project to other sites throughout the brain.
      Title: Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.
    6. Gucy2c knockout mice have a moderate cognitive and startle phenotype but have no ADHD-like phenotype.
      Title: Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes.
    7. This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity.
      Title: TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
    8. Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
      Title: Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
    9. Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival.
      Title: Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.
    10. Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome.
      Title: GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107510

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanylyl cyclase C
    Names
    STA receptor
    heat-stable enterotoxin receptor
    intestinal guanylate cyclase
    NP_001120790.1
    NP_659504.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127318.1 → NP_001120790.1  guanylyl cyclase C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001120790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1).
      Source sequence(s)
      AK136496, CF353627
      Consensus CDS
      CCDS51941.1
      UniProtKB/Swiss-Prot
      Q3UWA6, Q499D2, Q8JZQ6
      Related
      ENSMUSP00000032338.8, ENSMUST00000032338.10
      Conserved Domains (5) summary
      smart00044
      Location:787 → 978
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      smart00221
      Location:502 → 744
      STYKc; Protein kinase; unclassified specificity
      pfam00211
      Location:814 → 1001
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl10011
      Location:35 → 415
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:480 → 749
      PKc_like; Protein Kinases, catalytic domain

    2. NM_145067.3 → NP_659504.2  guanylyl cyclase C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK136496, CF353627
      Consensus CDS
      CCDS20653.1
      UniProtKB/Swiss-Prot
      Q3UWA6
      Related
      ENSMUSP00000077236.7, ENSMUST00000078095.11
      Conserved Domains (4) summary
      smart00044
      Location:763 → 954
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:790 → 977
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl10011
      Location:35 → 415
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:480 → 725
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136674282..136758740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UWA6.1 GenPept UniProtKB/Swiss-Prot:Q3UWA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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