Chmp3 charged multivesicular body protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chmp3provided by RGD
Official Full Name: charged multivesicular body protein 3provided by RGD
Primary source: RGD:708556
See related: EnsemblRapid:ENSRNOG00000007356 AllianceGenome:RGD:708556
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vps24
Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endosome to lysosome transport; positive regulation of cytokinesis; and regulation of endosome size. Located in early endosome; late endosome; and midbody. Orthologous to several human genes including CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 313.8), Lung (RPKM 275.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (105134860..105180862)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (103576453..103622566)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (99449213..99496156)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHMP3 (charged multivesicular body protein-3), of ESCRT-III localizes at the midbody; at the midbody, CHMP3 does not co-localize with Rab11, suggesting that it is not present on recycling endosomes
Title: A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes.
characterization of mVps24p; findings show it is selective in its binding to PtdIns(3,5)P2
Title: Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
NOT involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in multivesicular body-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane reassembly	ISO Inferred from Sequence Orthology more info
NOT involved_in nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of endosome size	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info
involved_in viral budding from plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in viral budding via host ESCRT complex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	IC Inferred by Curator more info	PubMed
part_of ESCRT III complex	ISO Inferred from Sequence Orthology more info
located_in amphisome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: charged multivesicular body protein 3

Names: Vps24p protein; chromatin-modifying protein 3; rVps24p; vacuolar protein sorting 24 homolog; vacuolar protein sorting-associated protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172331.1 → NP_758834.1 charged multivesicular body protein 3

See identical proteins and their annotated locations for NP_758834.1

Status: PROVISIONAL

Source sequence(s)

AY150169

UniProtKB/Swiss-Prot

Q8CGS4

UniProtKB/TrEMBL

A0A8I6AJK2, A6IA80

Related

ENSRNOP00000010253.2, ENSRNOT00000010253.6

Conserved Domains (1) summary

pfam03357
Location:18 → 187

Snf7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

105134860..105180862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236631.5 → XP_006236693.1 charged multivesicular body protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I6AJK2

Related

ENSRNOP00000093828.1, ENSRNOT00000119665.2

Conserved Domains (1) summary

pfam03357
Location:1 → 161

Snf7; Snf7