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    Zfp90 zinc finger protein 90 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp90provided by RGD
    Official Full Name
    zinc finger protein 90provided by RGD
    Primary source
    RGD:1563077
    See related
    EnsemblRapid:ENSRNOG00000020087 AllianceGenome:RGD:1563077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human ZFP90 (ZFP90 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 20.4), Lung (RPKM 17.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp90 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (51231748..51243039)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34321980..34333195)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38597657..38608951)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene protein arginine methyltransferase 7 Neighboring gene sphingomyelin phosphodiesterase 3 Neighboring gene ribosomal protein S12 like 1 Neighboring gene ribosomal protein L28 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Hata L, et al. J Mol Cell Cardiol, 2011 Jun. PMID 21284946
    2. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. Lange R, et al. DNA Cell Biol, 1995 Nov. PMID 7576184
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114532

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 90
    Names
    zfp-90
    zinc finger protein 90 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025765.2 → NP_001020936.1  zinc finger protein 90

      See identical proteins and their annotated locations for NP_001020936.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q4V8A8
      UniProtKB/TrEMBL
      A6IYW9
      Related
      ENSRNOP00000027209.4, ENSRNOT00000027209.6
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:198 → 625
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:552 → 572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:536 → 561
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      51231748..51243039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278196.1 → XP_063134266.1  zinc finger protein 90 isoform X3

    2. XM_063278197.1 → XP_063134267.1  zinc finger protein 90 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZLH2

    3. XM_063278195.1 → XP_063134265.1  zinc finger protein 90 isoform X1

      Related
      ENSRNOP00000099564.1, ENSRNOT00000125543.1

    4. XM_006255566.5 → XP_006255628.1  zinc finger protein 90 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:156 → 583
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:510 → 530
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:494 → 519
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8A8.1 GenPept UniProtKB/Swiss-Prot:Q4V8A8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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