Kif7 kinesin family member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif7provided by MGI
Official Full Name: kinesin family member 7provided by MGI
Primary source: MGI:MGI:1098239
See related: Ensembl:ENSMUSG00000050382 AllianceGenome:MGI:1098239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and positive regulation of smoothened signaling pathway. Acts upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Located in ciliary basal body and ciliary tip. Is expressed in several structures, including brain; genitourinary system; and secondary heart field. Used to study acrocallosal syndrome; ciliopathy; congenital diaphragmatic hernia; and hydrolethalus syndrome. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 4.8), CNS E11.5 (RPKM 4.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 45.09 cM; 7 D2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79347846..79365520, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79698098..79715772, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry.
Title: Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry.
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
Title: Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
Evolutionarily selected sequence differences enable immotile KIF7 motors to function not as transporters but as microtubule-based tethers of signaling complexes.
Title: Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.
Kif7-deficient thymocytes were unable to interpret changes in the Hedgehog signal. In addition, Kif7-deficiency reduced cell-surface MHCII expression on thymic epithelial cells.
Title: The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.
Mouse UBR3 poly-ubiquitinates Kif7, the mammalian homologue of Cos2. Finally, loss of UBR3 up-regulates Kif7 protein levels and decreases Hh signaling in cultured cells.
Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
Our data suggest that Kif7 may function to regulate the maintenance of the respiratory airway architecture by controlling cellular density, cell proliferation, and cycle exit through its role as a microtubule associated protein.
Title: KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
findings demonstrate that perturbations of Sufu and Kif7 affect Gli activity and recapitulate the full spectrum of vertebrate limb defects, ranging from severe truncation to polydactyly.
Title: Sufu and Kif7 in limb patterning and development.
results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
Kif7 localizes to the cilium tip, the site of microtubule plus ends, where it limits cilium length and controls cilium structure
Title: The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
Knockdown of Kif7, and retinoic acid receptors alpha (Rara), beta (Rarb), and gamma (Rarg) indicated that RA signaling is dependent on these genes to promote tendonogenesis within the embryonic diaphragm.
Title: Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary tip	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF7

Names: kinesin 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291222.2 → NP_001278151.1 kinesin-like protein KIF7 isoform 1

See identical proteins and their annotated locations for NP_001278151.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC158582

Consensus CDS

CCDS80739.1

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

UniProtKB/TrEMBL

J3QNW9

Related

ENSMUSP00000139359.2, ENSMUST00000183846.8

Conserved Domains (3) summary

COG1196
Location:734 → 1063

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:949 → 1202

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
NM_001412613.1 → NP_001399542.1 kinesin-like protein KIF7 isoform 3

Status: VALIDATED

Source sequence(s)

AC158582

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0
NM_001412614.1 → NP_001399543.1 kinesin-like protein KIF7 isoform 4

Status: VALIDATED

Source sequence(s)

AC158582
NM_010626.3 → NP_034756.2 kinesin-like protein KIF7 isoform 2

See identical proteins and their annotated locations for NP_034756.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC158582

Consensus CDS

CCDS52278.1

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

UniProtKB/TrEMBL

E9QMU1

Related

ENSMUSP00000061806.7, ENSMUST00000059836.13

Conserved Domains (3) summary

COG1196
Location:734 → 1062

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:948 → 1201

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

79347846..79365520 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540666.1 → XP_006540729.1 kinesin-like protein KIF7 isoform X3

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

Conserved Domains (3) summary

COG1196
Location:733 → 1062

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:948 → 1201

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006540667.1 → XP_006540730.1 kinesin-like protein KIF7 isoform X2

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

Conserved Domains (3) summary

COG1196
Location:733 → 1062

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:948 → 1201

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006540668.1 → XP_006540731.1 kinesin-like protein KIF7 isoform X4

See identical proteins and their annotated locations for XP_006540731.1

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

UniProtKB/TrEMBL

E9QMU1

Related

ENSMUSP00000139224.2, ENSMUST00000184137.2

Conserved Domains (3) summary

COG1196
Location:734 → 1062

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:948 → 1201

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006540665.4 → XP_006540728.1 kinesin-like protein KIF7 isoform X1

See identical proteins and their annotated locations for XP_006540728.1

UniProtKB/Swiss-Prot

B2RUB1, B7ZNG0

UniProtKB/TrEMBL

J3QNW9

Conserved Domains (3) summary

COG1196
Location:734 → 1063

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:949 → 1202

PRK11281; mechanosensitive channel MscK

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006540670.5 → XP_006540733.1 kinesin-like protein KIF7 isoform X5

Conserved Domains (2) summary

COG1196
Location:268 → 597

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK11281
Location:483 → 736

PRK11281; mechanosensitive channel MscK