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    Zfp945 zinc finger protein 945 [ Mus musculus (house mouse) ]

    Gene ID: 240041, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp945provided by MGI
    Official Full Name
    zinc finger protein 945provided by MGI
    Primary source
    MGI:MGI:2445132
    See related
    Ensembl:ENSMUSG00000059142 AllianceGenome:MGI:2445132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630033E08Rik; C730040L01Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and retina. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 2.5), CNS E11.5 (RPKM 2.4) and 23 other tissues See more
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    Genomic context

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    See Zfp945 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23065671..23086285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22846697..22867309, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11629 Neighboring gene STARR-seq mESC enhancer starr_42043 Neighboring gene predicted gene 5493 Neighboring gene STARR-seq mESC enhancer starr_42044 Neighboring gene zinc finger protein 946 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7496 Neighboring gene STARR-seq mESC enhancer starr_42045 Neighboring gene predicted gene, 32892 Neighboring gene zinc finger protein 40 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 128

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC240041

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110254.1 → NP_001103724.1  uncharacterized protein LOC240041 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK041739, AK164594, AK168592, BC078460
      Consensus CDS
      CCDS50005.1
      UniProtKB/TrEMBL
      F6WAU7
      Related
      ENSMUSP00000086074.7, ENSMUST00000088696.13
      Conserved Domains (5) summary
      smart00349
      Location:34 → 92
      KRAB; krueppel associated box
      COG5048
      Location:340 → 754
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:653 → 673
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:34 → 73
      KRAB; KRAB box
      pfam13465
      Location:469 → 494
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001404089.1 → NP_001391018.1  uncharacterized protein LOC240041 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC154486

    3. NM_177358.4 → NP_796332.2  uncharacterized protein LOC240041 isoform b

      See identical proteins and their annotated locations for NP_796332.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK041739, AK164594, AK168592, BC078460
      Consensus CDS
      CCDS50004.1
      UniProtKB/TrEMBL
      E9PYM8, Q66L36
      Related
      ENSMUSP00000124123.4, ENSMUST00000160457.10
      Conserved Domains (4) summary
      COG5048
      Location:376 → 765
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:632 → 652
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:337 → 361
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23065671..23086285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317465.3 → XP_017172954.1  uncharacterized protein LOC240041 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:338 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:594 → 614
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036160596.1 → XP_036016489.1  uncharacterized protein LOC240041 isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:333 → 722
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:589 → 609
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030249781.2 → XP_030105641.1  uncharacterized protein LOC240041 isoform X2

      UniProtKB/TrEMBL
      E9PYM8, Q66L36
      Conserved Domains (4) summary
      COG5048
      Location:376 → 765
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:632 → 652
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:337 → 361
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036160594.1 → XP_036016487.1  uncharacterized protein LOC240041 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:391 → 780
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:647 → 667
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 67
      KRAB; KRAB box
      pfam13465
      Location:352 → 376
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030249778.2 → XP_030105638.1  uncharacterized protein LOC240041 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:391 → 780
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:647 → 667
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 67
      KRAB; KRAB box
      pfam13465
      Location:352 → 376
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036160595.1 → XP_036016488.1  uncharacterized protein LOC240041 isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:333 → 722
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:589 → 609
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030249782.2 → XP_030105642.1  uncharacterized protein LOC240041 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:206 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:462 → 482
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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