Pcyox1 prenylcysteine oxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcyox1provided by MGI
Official Full Name: prenylcysteine oxidase 1provided by MGI
Primary source: MGI:MGI:1914131
See related: Ensembl:ENSMUSG00000029998 AllianceGenome:MGI:1914131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PCL1; Pcly; 1200015P13Rik
Summary: Enables prenylcysteine oxidase activity. Acts upstream of or within prenylcysteine catabolic process. Located in lysosome. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and respiratory system. Orthologous to human PCYOX1 (prenylcysteine oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 36.9), placenta adult (RPKM 35.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86362988..86374132, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86386006..86397150, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
Title: Prenylcysteine oxidase 1, an emerging player in atherosclerosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables farnesylcysteine lyase activity	IEA Inferred from Electronic Annotation more info
enables prenylcysteine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenylcysteine oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prenylcysteine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in prenylated protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prenylated protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in prenylated protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prenylcysteine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prenylcysteine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prenylcysteine oxidase 1

Names: prenylcysteine lyase

NP_001342616.1

EC 1.8.3.5

NP_080099.1

EC 1.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355687.1 → NP_001342616.1 prenylcysteine oxidase 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC153374, AC155947

UniProtKB/TrEMBL

Q99JK4

Conserved Domains (1) summary

pfam07156
Location:61 → 425

Prenylcys_lyase; Prenylcysteine lyase
NM_025823.4 → NP_080099.1 prenylcysteine oxidase 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_080099.1

Status: VALIDATED

Source sequence(s)

AK004799, AK134528

Consensus CDS

CCDS20311.1

UniProtKB/Swiss-Prot

Q3UHV6, Q69ZW0, Q8BZX1, Q9CQF9

UniProtKB/TrEMBL

Q3TVT6, Q3UYP2

Related

ENSMUSP00000032065.9, ENSMUST00000032065.15

Conserved Domains (2) summary

pfam07156
Location:130 → 494

Prenylcys_lyase; Prenylcysteine lyase

pfam13450
Location:39 → 106

NAD_binding_8; NAD(P)-binding Rossmann-like domain